ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2009
Clostridium difficile-associated disease in children with solid tumors.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Trends in Clostridioides difficile infection prevalence among pediatric cancer patients: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Guideline
- The impact of Clostridium difficile on paediatric surgical practice: a systematic review.Pediatric surgery international · 2014Pooled it
- Clostridioides difficile Infections in Inpatient Pediatric Oncology Patients: A Cohort Study Evaluating Risk Factors and Associated Outcomes.Journal of the Pediatric Infectious Diseases Society · 2021Article
- Infection withAccess microbiology · 2021Article
- Transmission ofInfection control and hospital epidemiology · 2020Article
- Investigation of Clostridium difficile ribotypes in symptomatic patients of a German pediatric oncology center.European journal of pediatrics · 2018Article
- Gastrointestinal and liver infections in children undergoing antineoplastic chemotherapy in the years 2000.World journal of gastroenterology · 2016Review
- The role of Clostridium difficile in the paediatric and neonatal gut - a narrative review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Review
- Variation in Risk of Hospital-Onset Clostridium difficile Infection Across β-Lactam Antibiotics in Children With New-Onset Acute Lymphoblastic Leukemia.Journal of the Pediatric Infectious Diseases Society · 2014Article
- Clostridium difficile as a cause of healthcare-associated diarrhoea among children in Auckland, New Zealand: clinical and molecular epidemiology.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Article
- Trends in Clostridium difficile infection and risk factors for hospital acquisition of Clostridium difficile among children with cancer.The Journal of pediatrics · 2013Article
- Clostridium difficile Infection in Children: Current State and Unanswered Questions.Journal of the Pediatric Infectious Diseases Society · 2012Review
- Clostridium difficile: an emerging pathogen in children.Discovery medicine · 2012Review
- Article
- Clostridium difficile infection in hospitalized children in the United States.Archives of pediatrics & adolescent medicine · 2011Article
- The association of Streptococcus bovis/gallolyticus with colorectal tumors: the nature and the underlying mechanisms of its etiological role.Journal of experimental & clinical cancer research : CR · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
goals of workThe goal of this study was to describe the incidence of Clostridium difficile-associated disease (CDAD) in children with solid tumours. PATIENTS AND
methodsAfter documentation of a case of C. difficile-associated pseudomembranous colitis in a patient with neuroblastoma, the presence of C. difficile toxins A and B was prospectively tested in all children undergoing antineoplastic chemotherapy for solid tumours or lymphomas at the "G. Gaslini" Children Hospital in Genoa who presented abdominal pain. MAIN
resultsFrom January 2005 to December 2006, nine (6%) out of 141 patients treated for solid tumours had C. difficile toxin A detected in their stools in the presence of abdominal symptoms including vomit, abdominal pain and diarrhoea. The majority of patients had a normal neutrophil count at onset of gastrointestinal disease No patient developed pseudomembranous colitis, and none died. All patients received antibiotics and/or antineoplastic drugs previously associated with CDAD.
conclusionsCDAD may be a complication of children with solid tumours. Since this disease may be life threatening and cause epidemic clusters, this possibility must be kept in mind for the differential diagnosis of abdominal diseases in children with cancer, especially in absence of neutropenia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.