ReviewCurrent genetics2008
Drug resistance and genetic mapping in Plasmodium falciparum.
Review in Current genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Article
- A review on molecular markers ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Review
- Malaria Genomics, Vaccine Development, and Microbiome.Pathogens (Basel, Switzerland) · 2023Review
- Efficient refolding and functional characterization ofBiochemistry and biophysics reports · 2021Article
- Global selective sweep of a highly inbred genome of the cattle parasiteProceedings of the National Academy of Sciences of the United States of America · 2019Article
- A Review of Pharmacogenetics of Antimalarials and Associated Clinical Implications.European journal of drug metabolism and pharmacokinetics · 2017Review
- Anti-malarial Drug Design by Targeting Apicoplasts: New Perspectives.Journal of pharmacopuncture · 2016Review
- Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria.Journal of visualized experiments : JoVE · 2015Article
- Article
- Genetics of chloroquine-resistant malaria: a haplotypic view.Memorias do Instituto Oswaldo Cruz · 2013Review
- Genetic diversity of Plasmodium falciparum and distribution of drug resistance haplotypes in Yemen.Malaria journal · 2013Article
- Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion.Nature communications · 2013Article
- Harnessing genomics and genome biology to understand malaria biology.Nature reviews. Genetics · 2012Review
- Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria.BMC genomics · 2012Article
- Application of genomics to field investigations of malaria by the international centers of excellence for malaria research.Acta tropica · 2012Review
- Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.Science (New York, N.Y.) · 2011Article
- Linkage maps from multiple genetic crosses and loci linked to growth-related virulent phenotype in Plasmodium yoelii.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum.PLoS genetics · 2011Article
- PfCRT-mediated drug transport in malarial parasites.Biochemistry · 2011Review
- An optimized microarray platform for assaying genomic variation in Plasmodium falciparum field populations.Genome biology · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Drug resistance in malaria parasites is a serious public health burden, and resistance to most of the antimalarial drugs currently in use has been reported. A better understanding of the molecular mechanisms of drug resistance is urgently needed to slow or circumvent the spread of resistance, to allow local treatments to be deployed more effectively to prolong the life span of the current drugs, and to develop new drugs. Although mutations in genes determining resistance to drugs such as chloroquine and the antifolates have been identified, we still do not have a full understanding of the resistance mechanisms, and genes that contribute to resistance to many other drugs remain to be discovered. Genetic mapping is a powerful tool for the identification of mutations conferring drug resistance in malaria parasites because most drug-resistant phenotypes were selected within the past 60 years. High-throughput methods for genotyping large numbers of single nucleotide polymorphisms (SNPs) and microsatellites (MSs) are now available or are being developed, and genome-wide association studies for malaria traits will soon become a reality. Here we discuss strategies and issues related to mapping genes contributing to drug resistance in the human malaria parasite Plasmodium falciparum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.