ArticleThe Journal of clinical investigation2008
Prenatal maternal diet affects asthma risk in offspring.
Article in The Journal of clinical investigation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
- Trial
- Dietary exposures, epigenetics and pubertal tempo.Environmental epigenetics · 2019Article
- Regulatory T Cells in Allergy and Asthma.Frontiers in pediatrics · 2017Review
- Maternal Genetic Variants of IL4/IL13 Pathway Genes on IgE With "Western or Eastern Environments/Lifestyles".Allergy, asthma & immunology research · 2014Article
- Epigenomic programing: a future way to health?Microbial ecology in health and disease · 2014Review
- The causal effect of red blood cell folate on genome-wide methylation in cord blood: a Mendelian randomization approach.BMC bioinformatics · 2013Article
- Unraveling the genetic basis of aspirin hypersensitivity in asthma beyond arachidonate pathways.Allergy, asthma & immunology research · 2013Review
- DNA methylome signature in rheumatoid arthritis.Annals of the rheumatic diseases · 2013Article
- Epigenetics, asthma, and allergic diseases: a review of the latest advancements.Current allergy and asthma reports · 2012Review
- Vitamin D and asthma.Dermato-endocrinology · 2012Article
- The search for genetic variants and epigenetics related to asthma.Allergy, asthma & immunology research · 2011Article
- Functions of T cells in asthma: more than just T(H)2 cells.Nature reviews. Immunology · 2010Review
- Tolerizing allergic responses in the lung.Mucosal immunology · 2010Review
- Ecogenomics of respiratory diseases of public health significance.Annual review of public health · 2010Review
- Dietary, metabolic, and potentially environmental modulation of the lysine acetylation machinery.International journal of cell biology · 2010Article
- Regulatory T cells in asthma.Immunity · 2009Review
- Update on allergies in pregnancy, lactation, and early childhood.The Journal of allergy and clinical immunology · 2009Review
Corrections and comments
- Comment on
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Recently, epigenetic-mediated mechanisms - which involve heritable changes in gene expression in the absence of alterations in DNA sequences - have been proposed as contributing to asthma. In this issue of the JCI, Hollingsworth and colleagues report on the effect of prenatal maternal dietary intake of methyl donors on the risk of allergic airway disease in offspring in mice and show that these effects involve epigenetic regulation (see the related article beginning on page 3462). Supplementation of the maternal diet with methyl donors was associated with greater airway allergic inflammation and IgE production in F1 and, to some extent, F2 progeny. Site-specific differences in DNA methylation and reduced transcriptional activity were detected. If these findings are confirmed, a new paradigm for asthma pathogenesis may be emerging.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.