ArticleThe Journal of clinical investigation2008
In utero supplementation with methyl donors enhances allergic airway disease in mice.
Article in The Journal of clinical investigation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 186 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
186 citing papers in PubMed, 5 syntheses or guidelines pooled it, 330 citations in OpenAlex.
- The role of epigenetics in respiratory health in urban populations in low and middle-income countries.Global health, epidemiology and genomics · 2019Pooled it
- Association of maternal folate intake during pregnancy with infant asthma risk.Scientific reports · 2019Pooled it
- Associations of genetic determinants of serum vitamin B12 and folate concentrations with hay fever and asthma: a Mendelian randomization meta-analysis.European journal of clinical nutrition · 2018Pooled it
- Pooled it
- Prenatal folic acid and risk of asthma in children: a systematic review and meta-analysis.The American journal of clinical nutrition · 2013Pooled it
- Clinical markers of asthma and IgE assessed in parents before conception predict asthma and hayfever in the offspring.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2017Trial
- Maternal body mass index in early pregnancy and offspring asthma, rhinitis and eczema up to 16 years of age.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Trial
- Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study.The American journal of clinical nutrition · 2013Trial
- Emerging roles of epigenetic regulators during lung development.Cell death & disease · 2025Review
- Epigenetics and Asthma: A Systematic Review.Cureus · 2024Review
- The Role of Vitamins in the Pathogenesis of Asthma.International journal of molecular sciences · 2023Review
- Trained innate immunity, epigenetics, and food allergy.Frontiers in allergy · 2023Review
- Review
- Epigenetic regulation of immune function in asthma.The Journal of allergy and clinical immunology · 2022Review
- Periconceptional folic acid supplementation is a risk factor for childhood asthma: a case-control study.BMC pregnancy and childbirth · 2022Article
- Relationship between maternal folic acid supplementation during pregnancy and risk of childhood asthma: Systematic review and dose-response meta-analysis.Frontiers in pediatrics · 2022Review
- Diet and asthma: Is the sum more important than the parts?The Journal of allergy and clinical immunology · 2021Article
- Epigenetic Changes Induced by Maternal Factors during Fetal Life: Implication for Type 1 Diabetes.Genes · 2021Review
- Folic Acid and Infant Allergy: Avoiding Rash Judgments.The Journal of nutrition · 2021Article
- Overview of Folic Acid Supplementation Alone or in Combination with Vitamin B12 in Dairy Cattle during Periparturient Period.Metabolites · 2020Review
126 more citing papers are in PubMed but not listed here.
Corrections and comments
- Retraction · 2016-05-02Unreliable Data · Unreliable Results and/or Conclusions ·
- Commented on by
- Commented on by
- Retracted
Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
Asthma is a complex heritable disease that is increasing in prevalence and severity, particularly in developed countries such as the United States, where 11% of the population is affected. The contribution of environmental and genetic factors to this growing epidemic is currently not well understood. We developed the hypothesis, based on previous literature, that changes in DNA methylation resulting in aberrant gene transcription may enhance the risk of developing allergic airway disease. Our findings indicate that in mice, a maternal diet supplemented with methyl donors enhanced the severity of allergic airway disease that was inherited transgenerationally. Using a genomic approach, we discovered 82 gene-associated loci that were differentially methylated after in utero supplementation with a methyl-rich diet. These methylation changes were associated with decreased transcriptional activity and increased disease severity. Runt-related transcription factor 3 (Runx3), a gene known to negatively regulate allergic airway disease, was found to be excessively methylated, and Runx3 mRNA and protein levels were suppressed in progeny exposed in utero to a high-methylation diet. Moreover, treatment with a demethylating agent increased Runx3 gene transcription, further supporting our claim that a methyl-rich diet can affect methylation status and consequent transcriptional regulation. Our findings indicate that dietary factors can modify the heritable risk of allergic airway disease through epigenetic mechanisms during a vulnerable period of fetal development in mice.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.