ArticleCell cycle (Georgetown, Tex.)2008
Speedy/Ringo C regulates S and G2 phase progression in human cells.
Article in Cell cycle (Georgetown, Tex.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
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- A novel prognostic two-gene signature for triple negative breast cancer.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- The transcriptome dynamics of single cells during the cell cycle.Molecular systems biology · 2020Article
- Promotion of G1/S Transition and Inhibition of Inflammatory Cytokine Production by Hydroxypyridinone-Coumarin in Osteoarthritis Rats.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Article
- Effects of allicin on the proliferation and cell cycle of chondrocytes.International journal of clinical and experimental pathology · 2015Article
- Role of LM23 in cell proliferation and apoptosis and its expression during the testis development.Asian journal of andrology · 2013Article
- Evolution of the Cdk-activator Speedy/RINGO in vertebrates.Cellular and molecular life sciences : CMLS · 2012Article
- Determinants for activation of the atypical AGC kinase Greatwall during M phase entry.Molecular and cellular biology · 2012Article
- Adhesion molecule periplakin is involved in cellular movement and attachment in pharyngeal squamous cancer cells.BMC cell biology · 2011Article
- Upregulation of the cell-cycle regulator RGC-32 in Epstein-Barr virus-immortalized cells.PloS one · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cyclin-dependent kinases (CDKs) control cell cycle transitions and progression. In addition to their activation via binding to cyclins, CDKs can be activated via binding to an unrelated class of cell cycle regulators termed Speedy/Ringo (S/R) proteins. Although mammals contain at least five distinct Speedy/Ringo homologues, the specific functions of members of this growing family of CDK activators remain largely unknown. We investigated the cell cycle roles of human Speedy/Ringo C in HEK293 cells. Down-regulation of Speedy/Ringo C by RNA interference delayed S and G(2) progression whereas ectopic expression had the opposite effect, reducing S and G(2)/M populations. Double thymidine arrest and release experiments showed that overexpression of Speedy/Ringo C promoted late S phase progression. Using a novel three-color FACS protocol to determine the length of G(2) phase, we found that the suppression of Speedy/Ringo C by RNAi prolonged G(2) phase by approximately 30 min whereas ectopic expression of Speedy/Ringo C shortened G(2) phase by approximately 25 min. In addition, overexpression of Speedy/Ringo C disrupted the G(2) DNA damage checkpoint, increased cell death and caused a cell cycle delay at the G(1)-to-S transition. These observations indicate that CDK-Speedy/Ringo C complexes positively regulate cell cycle progression during the late S and G(2) phases of the cell cycle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.