ArticleMolecular pharmacology2008
Identification of quinolines that inhibit melanogenesis by altering tyrosinase family trafficking.
Article in Molecular pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Dual Modulatory Effects of Phytochemicals fromMolecules (Basel, Switzerland) · 2025Article
- Newly Designed Quinazolinone Derivatives as Novel Tyrosinase Inhibitor: Synthesis, Inhibitory Activity, and Mechanism.Molecules (Basel, Switzerland) · 2022Article
- Catechin-7-International journal of medical sciences · 2022Article
- GIF-2209, an Oxindole Derivative, Accelerates Melanogenesis and Melanosome Secretion via the Modification of Lysosomes in B16F10 Mouse Melanoma Cells.Molecules (Basel, Switzerland) · 2021Article
- Melanin decolorization by lysosome-related extract in Saccharomyces cerevisiae modified to overproduce glutathione peroxidase.Applied microbiology and biotechnology · 2021Article
- Inhibition of melanogenesis by jineol from Scolopendra subspinipes mutilans via MAP-Kinase mediated MITF downregulation and the proteasomal degradation of tyrosinase.Scientific reports · 2017Article
- Efficient Percutaneous Delivery of the Antimelanogenic Agent Glabridin Using Cationic Amphiphilic Chitosan Micelles.PloS one · 2016Article
- Callicarpa longissima extract, carnosol-rich, potently inhibits melanogenesis in B16F10 melanoma cells.Journal of natural medicines · 2016Article
- Chemical composition, antioxidant, and enzyme inhibitory activities of the essential oils of threeFood science and biotechnology · 2016Article
- Chloroquine-containing compounds: a patent review (2010 - 2014).Expert opinion on therapeutic patents · 2015Review
- Tyrosinase inhibitory activity of a glucosylated hydroxystilbene in mouse melan-a melanocytes.Journal of natural products · 2014Article
- 9-cis retinoic acid is the ALDH1A1 product that stimulates melanogenesis.Experimental dermatology · 2013Article
- Article
- 4-Chloro-2,5-dimethyl-quinoline.Acta crystallographica. Section E, Structure reports online · 2010Article
- Mechanisms regulating skin pigmentation: the rise and fall of complexion coloration.International journal of molecular sciences · 2009Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A series of quinolines, including chloroquine and quinine, were identified as potent pigmentation inhibitors through screening a compound library in murine melanocytes. Structure-activity relationship analysis indicated that 4-substituted amino groups with a tertiary amine side chain, such as chloroquine, were associated with robust inhibitory activity. In contrast to many previously identified pigmentation inhibitors, these newly identified inhibitors had no effect on either the level or the enzymatic activity of tyrosinase, the rate-limiting enzyme in melanin production. Rather, our results showed that these quinolines inhibited melanogenesis by disrupting the intracellular trafficking of tyrosinase-related proteins and lysosome-associated membrane protein 1 (Lamp-1). In treated melanocytes, tyrosinase and tyrosinase-related protein 1 accumulated in Lamp-1-positive perinuclear organelles instead of melanosomes, thus preventing melanogenesis. The depigmenting abilities of chloroquine and quinine salicylate were assessed in a human skin equivalent model (MelanoDerm). Both compounds were considerably more effective than arbutin, a widely used lightening agent. Our results indicate that quinolines may be useful agents for "cosmeceutical" skin lightening and treatment of hyperpigmentation disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.