ArticleEndocrinology2009
Regenerative potentials of the murine thyroid in experimental autoimmune thyroiditis: role of CD24.
Article in Endocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets.Frontiers in immunology · 2025Article
- Checkpoint CD24 function on tumor and immunotherapy.Frontiers in immunology · 2024Review
- Progress Toward and Challenges Remaining for Thyroid Tissue Regeneration.Endocrinology · 2023Review
- Identification of transcriptomic signatures and crucial pathways involved in non-alcoholic steatohepatitis.Endocrine · 2021Article
- A Stem Cell Surge During Thyroid Regeneration.Frontiers in endocrinology · 2020Article
- Functions of stem cells of thyroid glands in health and disease.Reviews in endocrine & metabolic disorders · 2019Review
- An in vivo model for thyroid regeneration and folliculogenesis.Laboratory investigation; a journal of technical methods and pathology · 2018Article
- Review
- CD24: from a Hematopoietic Differentiation Antigen to a Genetic Risk Factor for Multiple Autoimmune Diseases.Clinical reviews in allergy & immunology · 2016Review
- Thyroid regeneration: how stem cells play a role?Frontiers in endocrinology · 2014Review
- Diosgenin relieves goiter via the inhibition of thyrocyte proliferation in a mouse model of Graves' disease.Acta pharmacologica Sinica · 2014Article
- Cell-type-specific expression of STAT transcription factors in tissue samples from patients with lymphocytic thyroiditis.Endocrine pathology · 2012Article
- Clinical review: The emerging cell biology of thyroid stem cells.The Journal of clinical endocrinology and metabolism · 2011Review
- CD24: from A to Z.Cellular & molecular immunology · 2010Review
- Influence of signal transducer and activator of transcription-1 signaling on thyroid morphology and function.Endocrinology · 2009Article
- CD24 blunts oral squamous cancer development and dampens the functional expansion of myeloid-derived suppressor cells.OncoimmunologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Hashimoto thyroiditis can be partially reproduced in mice by immunization with thyroglobulin or, more recently, thyroperoxidase. This experimental autoimmune thyroiditis (EAT) model has been extensively characterized during early disease phases (up to d 35 after immunization). By extending the analysis of EAT to 100 d after immunization, we noted a remarkable regenerative capacity of the thyroid and the expression of Oct-4, suggesting in vivo the existence of adult thyroid stem cells. After an almost complete destruction of the follicular architecture, occurring between d 21 and 28, the thyroid was capable of restoring its follicles and reducing the mononuclear infiltration, so that by d 100 after immunization, it regained its normal morphology and function. During this regeneration process, thyrocytes expressed high levels of CD24. We therefore assessed the role of CD24 in thyroid regeneration by inducing EAT in mice lacking CD24. Regeneration was faster in the absence of CD24, likely a consequence of the effect of CD24 on the infiltrating lymphocytes. The study suggests that the EAT model can also be used as a tool to investigate adult thyroid stem cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.