Evidence map›Paper›PMID 18801863›Full record

ArticlePhysical therapy2008

Diabetes-related microvascular and macrovascular diseases in the physical therapy setting.

W Todd Cade

3 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph

Article in Physical therapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 399 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
399citing papers in PubMed, 6 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05343767 nacompletedstarted 2018, after this paper: background citation

A Phase II, Randomized, Double Blind, Double Dummy, Active-Controlled Clinical Trial to Investigate the Efficacy and Safety of Low-Glu in Patients Newly Diagnosed With Type II Diabetes Mellitus

Ran2018Enrolled198Registered outcomes6Posted comparisons0ConditionsType2 Diabetes MellitusArmsMetformin, Natural Wellness Low-Glu high dose, Natural Wellness Low-Glu low dose
Open the trial in the graph
NCT05082402 completednot on this mapstarted 2021, after this paper: background citation

Imaging of Retinochoroidal Vasculature in Patients Being Assessed for Cardiovascular Disease

TypeobservationalSponsorNorthwestern UniversityRan2021 to 2023Enrolled42ConditionsCardiovascular Diseases, Retina, ChangeArmsSwept Source Optical Coherence Tomography Angiography
NCT07784543 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effects of Aerobic Exercise on Shoulder Pain, Disability, and Ultrasonographic Outcomes in Patients With Type 2 Diabetes Mellitus With Supraspinatus Tendinopathy :A Randomized Controlled Trial

TypeinterventionalSponsorPamukkale UniversityRan2026 to 2027Enrolled24ConditionsSupraspinatus Tendinopathy, Type 2 Diabetes Mellitus (T2DM)ArmsConventional Shoulder Rehabilitation, Aerobic Exercise
3 · Its place in the literature

Who cites it

399 citing papers in PubMed, 6 syntheses or guidelines pooled it, 1,067 citations in OpenAlex.

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339 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

W Todd CadeWashington University School of Medicine, Campus Box 8502, 4444 Forest Park Blvd, St Louis, MO 63108, USA. cadet@wusm.wustl.edu
Washington University in St. Louis · US

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
NIDDK NIH HHS P30 DK056341PHS HHS K0K074343A
6 · The paper itself

Abstract

Physical therapists commonly treat people with diabetes for a wide variety of diabetes-associated impairments, including those from diabetes-related vascular disease. Diabetes is associated with both microvascular and macrovascular diseases affecting several organs, including muscle, skin, heart, brain, and kidneys. A common etiology links the different types of diabetes-associated vascular disease. Common risk factors for vascular disease in people with diabetes, specifically type 2 diabetes, include hyperglycemia, insulin resistance, dyslipidemia, hypertension, tobacco use, and obesity. Mechanisms for vascular disease in diabetes include the pathologic effects of advanced glycation end product accumulation, impaired vasodilatory response attributable to nitric oxide inhibition, smooth muscle cell dysfunction, overproduction of endothelial growth factors, chronic inflammation, hemodynamic dysregulation, impaired fibrinolytic ability, and enhanced platelet aggregation. It is becoming increasingly important for physical therapists to be aware of diabetes-related vascular complications as more patients present with insulin resistance and diabetes. The opportunities for effective physical therapy interventions (such as exercise) are significant.

Indexed as

Physical Therapy ModalitiesVascular DiseasesAnimalsDiabetes ComplicationsExercise TherapyHumansPeripheral Vascular DiseasesRisk FactorsStroke

Identifiers

PMID18801863
PMCPMC2579903
OpenAlexW2155905771

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.