ArticlePhysical therapy2008
Inflammatory osteolysis in diabetic neuropathic (charcot) arthropathies of the foot.
Article in Physical therapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Diabetes mellitus and gait dysfunction: possible explanatory factors.Physical therapy · 2008Trial
- Plantar stresses on the neuropathic foot during barefoot walking.Physical therapy · 2008Trial
- Foot-specific exercise intervention for forefoot deformity in individuals with type 2 diabetes and peripheral neuropathy: A randomized controlled clinical trial with 3-year follow-up.Brazilian journal of physical therapyTrial
- Rate of tarsal and metatarsal bone mineral density change in adults with diabetes mellitus and peripheral neuropathy: a longitudinal study.Journal of foot and ankle research · 2023Article
- Duration of total contact casting for resolution of acute Charcot foot: a retrospective cohort study.Journal of foot and ankle research · 2021Article
- Infrared dermal thermometry is highly reliable in the assessment of patients with Charcot neuroarthropathy.Journal of foot and ankle research · 2020Article
- Bone Mineral Density in Diabetes Mellitus Foot Patients for Prediction of Diabetic Neuropathic Osteoarthropathic Fracture.Journal of bone metabolism · 2020Article
- Accelerated Cortical Osteolysis of Metatarsals in Charcot Neuroarthropathy: A Cross-Sectional Observational Study.JBMR plus · 2019Article
- Radiographic Presentation of Delayed Diagnosis of Charcot Foot in a 56-Year-Old Patient With No Reported History of Diabetes: A Case Report.Journal of chiropractic medicine · 2019Article
- Article
- Pathogenesis and potential relative risk factors of diabetic neuropathic osteoarthropathy.Journal of orthopaedic surgery and research · 2017Review
- Persistent inflammation with pedal osteolysis 1year after Charcot neuropathic osteoarthropathy.Journal of diabetes and its complications · 2017Article
- Molecular Mechanisms of Obesity-Induced Osteoporosis and Muscle Atrophy.Frontiers in physiology · 2016Review
- Muscle-bone and fat-bone interactions in regulating bone mass: do PTH and PTHrP play any role?Endocrine · 2014Review
- Proton magnetic resonance spectroscopy in the evaluation of patients with acute Charcot neuro-osteoarthropathy.European radiology · 2013Article
- Pedal bone density, strength, orientation, and plantar loads preceding incipient metatarsal fracture after charcot neuroarthropathy: 2 case reports.The Journal of orthopaedic and sports physical therapy · 2013Article
- Biomolecular basis of the role of diabetes mellitus in osteoporosis and bone fractures.World journal of diabetes · 2013Article
- Developing an evidence-based clinical pathway for the assessment, diagnosis and management of acute Charcot Neuro-Arthropathy: a systematic review.Journal of foot and ankle research · 2013Article
- Neuropathic midfoot deformity: associations with ankle and subtalar joint motion.Journal of foot and ankle research · 2013Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveOsteolysis and low bone mineral density (BMD) are underappreciated consequences of several chronic diseases that may elevate the risk for fracture. The purpose of this study was to assess tarsal BMD associated with acute inflammation (ie, inflammatory osteolysis) in individuals with chronic diabetes mellitus (DM), peripheral neuropathy (PN), and recent-onset neuropathic (Charcot) arthropathy (NCA) of the foot. RESEARCH DESIGN AND
methodsThis was a case-control study of 32 people (11 men, 21 women) with DM, PN, and NCA of the foot or ankle. The subjects with DM, PN, and NCA were compared with 64 age-, sex-, and race-matched control subjects (24 men, 40 women) without DM, PN or NCA. Within the first 3 weeks of cast immobilization, BMD was estimated in both calcanei using quantitative ultrasonometry. Acute inflammation was confirmed by comparing skin temperature differences between the feet of the subjects with DM, PN, and NCA and the feet of the control subjects.
resultsSkin temperature differences averaged 6.7 degrees F (SD=4.0 degrees F) (involved foot minus noninvolved foot) in the feet of the subjects with DM, PN, and NCA compared with 0.0 degrees F (SD=1.3 degrees F) in the feet of the control subjects. Calcaneal BMD averaged 384 mg/cm(2) (SD=110) in the involved feet and 467 mg/cm(2) (SD=123) in the noninvolved feet of the subjects with DM, PN, and NCA and 545 mg/cm(2) (SD=121) in combined right and left feet of the control subjects.
conclusionsInflammation in individuals with DM, PN, and NCA may contribute to or exacerbate a rapid loss of BMD. Inflammatory osteolysis may be a prominent factor responsible for both the spontaneous onset of neuropathic fracture and the insidious and progressive foot deformity that is the hallmark of the chronic Charcot foot.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.