ArticleLipids in health and disease2008
Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease.
Article in Lipids in health and disease, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Analysis of Differentially Expressed Genes in Coronary Artery Disease by Integrated Microarray Analysis.Biomolecules · 2019Article
- The association between apolipoprotein A1-C3-A5 gene cluster promoter polymorphisms and risk of ischemic stroke in the northern Chinese Han population.The Journal of international medical research · 2017Article
- Quantitative trait loci at the 11q23.3 chromosomal region related to dyslipidemia in the population of Andhra Pradesh, India.Lipids in health and disease · 2017Article
- Genetic determinants of clinical heterogeneity of the coronary artery disease in the population of Hyderabad, India.Human genomics · 2017Article
- Optimization of PCR Condition: The First Study of High Resolution Melting Technique for Screening ofYonago acta medica · 2017Article
- APOC3 rs2070666 Is Associated with the Hepatic Steatosis Independently of PNPLA3 rs738409 in Chinese Han Patients with Nonalcoholic Fatty Liver Diseases.Digestive diseases and sciences · 2016Article
- Article
- Article
- Genetic epidemiology of coronary artery disease: an Asian Indian perspective.Journal of genetics · 2015Review
- Effect of apolipoprotein A1 genetic polymorphisms on lipid profiles and the risk of coronary artery disease.Diagnostic pathology · 2015Article
- Apolipoprotein C3 genetic polymorphisms are associated with lipids and coronary artery disease in a Chinese population.Lipids in health and disease · 2014Article
- Association of APOA5 rs662799 and rs3135506 polymorphisms with arterial hypertension in Moroccan patients.Lipids in health and disease · 2014Article
- Haplotype analysis of Apo AI-CIII-AIV gene cluster and lipids level: Tehran Lipid and Glucose Study.Endocrine · 2012Article
- Associations of polymorphisms in the apolipoprotein APOA1-C3-A5 gene cluster with acute coronary syndrome.Journal of biomedicine & biotechnology · 2012Article
- APOA1 gene polymorphisms in the South Asian immigrant population in the United States.Indian journal of human genetics · 2011Article
- Apolipoprotein A1/C3/A5 haplotypes and serum lipid levels.Lipids in health and disease · 2011Article
- Metabolic syndrome in South Asian immigrants: more than low HDL requiring aggressive management.Lipids in health and disease · 2011Article
- Interactions of the apolipoprotein A5 gene polymorphisms and alcohol consumption on serum lipid levels.PloS one · 2011Article
- Influence of genetic variants in the apolipoprotein A5 and C3 gene on lipids, lipoproteins, and its association with coronary artery disease in Indians.Journal of community genetics · 2010Article
- Interactions of the apolipoprotein C-III 3238C>G polymorphism and alcohol consumption on serum triglyceride levels.Lipids in health and disease · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe APOA1-C3-A5 gene cluster plays an important role in the regulation of lipids. Asian Indians have an increased tendency for abnormal lipid levels and high risk of Coronary Artery Disease (CAD). Therefore, the present study aimed to elucidate the relationship of four single nucleotide polymorphisms (SNPs) in the Apo11q cluster, namely the -75G>A, +83C>T SNPs in the APOA1 gene, the Sac1 SNP in the APOC3 gene and the S19W variant in the APOA5 gene to plasma lipids and CAD in 190 affected sibling pairs (ASPs) belonging to Asian Indian families with a strong CAD history. METHODS &
resultsGenotyping and lipid assays were carried out using standard protocols. Plasma lipids showed a strong heritability (h2 48% - 70%; P < 0.0001). A subset of 77 ASPs with positive sign of Logarithm of Odds (LOD) score showed significant linkage to CAD trait by multi-point analysis (LOD score 7.42, P < 0.001) and to Sac1 (LOD score 4.49) and -75G>A (LOD score 2.77) SNPs by single-point analysis (P < 0.001). There was significant proportion of mean allele sharing (pi) for the Sac1 (pi 0.59), -75G>A (pi 0.56) and +83C>T (pi 0.52) (P < 0.001) SNPs, respectively. QTL analysis showed suggestive evidence of linkage of the Sac1 SNP to Total Cholesterol (TC), High Density Lipoprotein-cholesterol (HDL-C) and Apolipoprotein B (ApoB) with LOD scores of 1.42, 1.72 and 1.19, respectively (P < 0.01). The Sac1 and -75G>A SNPs along with hypertension showed maximized correlations with TC, TG and Apo B by association analysis.
conclusionThe APOC3-Sac1 SNP is an important genetic variant that is associated with CAD through its interaction with plasma lipids and other standard risk factors among Asian Indians.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.