ArticleGenes and immunity2009
The IL-10R1 S138G loss-of-function allele and ulcerative colitis.
Article in Genes and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Association between polymorphisms in the promoter region of interleukin-10 and susceptibility to inflammatory bowel disease.Molecular biology reports · 2014Pooled it
- Novel missense mutation in the NOD2 gene in a patient with early onset ulcerative colitis: causal or chance association?International journal of molecular sciences · 2014Article
- The molecular basis of IL-10 function: from receptor structure to the onset of signaling.Current topics in microbiology and immunology · 2014Review
- Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans.Advances in immunology · 2014Review
- IFNβ autocrine feedback is required to sustain TLR induced production of MCP-1 in macrophages.FEBS letters · 2013Article
- Exome sequencing identifies novel compound heterozygous mutations of IL-10 receptor 1 in neonatal-onset Crohn's disease.Genes and immunity · 2012Article
- An intracytoplasmic IL-10 receptor variant permits rapid reduction in STAT3 activation.Genes and immunity · 2011Article
- Effect of host genetics on the development of cytomegalovirus retinitis in patients with AIDS.The Journal of infectious diseases · 2010Article
- Effect of host genetics on incidence of HIV neuroretinal disorder in patients with AIDS.Journal of acquired immune deficiency syndromes (1999) · 2010Article
- Differential signaling of cmvIL-10 through common variants of the IL-10 receptor 1.European journal of immunology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
Abstract
Genetic predisposition is a risk factor for the development of inflammatory bowel diseases (IBDs). Disruption of the interleukin (IL)-10 pathway in mice causes intestinal inflammation similar to human IBD. Two common non-synonymous IL-10R1 variants, S138G and G330R, were cloned and expressed in HeLa and Ba/F3. A reduction in IL-10-induced STAT1 and STAT3 activation was seen for IL-10R1-S138G (but not IL-10R1-G330R) by phosphospecific western blotting in both cell types. When analyzing 52 world populations for the presence of IL-10R1 variants, a strong dissimilarity was found between major geographical regions. In addition, when 182 IBD-parent trios were genotyped for both variants, a reduced transmission of haplotype -7 (carrying the S138G variant allele) to offspring with ulcerative colitis (UC) was observed. This UC-protective effect of S138G was confirmed in a Hungarian cohort (n=185, allele frequency 11.6 versus 17.5%; P=0.017) but not in an independent Belgian cohort (n=666, allele frequency 15.9 versus 15.5%; P=0.8). In conclusion, the IL-10R1 S138G variant is a loss-of-function allele for IL-10-induced STAT1 and STAT3 activation but does not protect from UC susceptibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.