ArticleMedicine and science in sports and exercise2008
Relationship of running intensity to hypertension, hypercholesterolemia, and diabetes.
Article in Medicine and science in sports and exercise, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Cardiorespiratory fitness, muscular strength and risk of type 2 diabetes: a systematic review and meta-analysis.Diabetologia · 2019Pooled it
- High-intensity interval training: Modulating interval duration in overweight/obese men.The Physician and sportsmedicine · 2015Trial
- Effects of high vs. moderate exercise intensity during interval training on lipids and adiponectin levels in obese young females.European journal of applied physiology · 2013Trial
- Long- and Short-Term High-Intensity Interval Training on Lipid Profile and Cardiovascular Disorders in Obese Male Adolescents.Children (Basel, Switzerland) · 2023Article
- Effects of Turmeric Concentrate on Cardiovascular Risk Factors and Exercise-Induced Oxidative Stress in Healthy Volunteers; an Exploratory Study.Advanced pharmaceutical bulletin · 2023Article
- Can running-related injuries be prevented through an online behavioural intervention in adult novice runners? Results of a randomised controlled trial.BMJ open sport & exercise medicine · 2023Article
- Health status of recreational runners over 10-km up to ultra-marathon distance based on data of the NURMI Study Step 2.Scientific reports · 2022Article
- High-Intensity Interval Training for Knee Osteoarthritis: A Pilot Study.ACR open rheumatology · 2021Article
- Gender and Exercise in Relation to Obesity in Greek Elderly Population.International journal of environmental research and public health · 2020Article
- Low utilization of glucose in the liver causes diet-induced hypercholesterolemia in exogenously hypercholesterolemic rats.PloS one · 2020Article
- Leisure-Time Running Reduces the Risk of Incident Type 2 Diabetes.The American journal of medicine · 2019Article
- Kinematic, Cardiopulmonary, and Metabolic Responses of Overweight Runners While Running at Self-Selected and Standardized Speeds.PM & R : the journal of injury, function, and rehabilitation · 2016Article
- Application of pre-participation cardiovascular screening guidelines to novice older runners and endurance athletes.SAGE open medicine · 2016Article
- Dose-response associations between cycling activity and risk of hypertension in regular cyclists: The UK Cycling for Health Study.Journal of human hypertension · 2015Observational
- Association between physical activity and peripheral artery disease and carotid artery stenosis in a self-referred population of 3 million adults.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Quality of life in China rural-to-urban female migrant factory workers: a before-and-after study.Health and quality of life outcomes · 2013Article
- How do general practitioners in Denmark promote physical activity?Scandinavian journal of primary health care · 2012Article
- Physical activity in different domains and health-related quality of life: a population-based study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2010Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purposeTo estimate the independent relationships of running intensity with antihypertensive, LDL-cholesterol-lowering, and antidiabetic medication use when adjusted for running volume (km x d(-1)).
methodsSelf-reported medication use was compared cross-sectionally to running pace (m x s(-1) during usual run) in 25,552 male and 29,148 female National Runners' Health Study participants.
resultsThe men ran a mean +/- SD of 5.2 +/- 3.1 km x d(-1) at 3.3 +/- 0.5 m x s(-1) (8.3 +/- 1.4 min x mile(-1)) and the women 4.7 +/- 2.9 km x wk(-1) at 3.0 +/- 0.4 m x s(-1) (9.2 +/- 1.8 min x mile(-1)). When adjusted for kilometers per day, each meter-per-second increment in intensity in men and women reduced the odds for antihypertensive drug use by 54% and 46%, respectively, reduced the odds for LDL-cholesterol-lowering medication use by 55% and 48%, respectively, and reduced the odds for antidiabetic medication use by 50% and 75%, respectively (all P < 0.0001). Compared with men who ran slower than 10 min x mile(-1), the odds for medication use in those who ran or exceeded a 7-min x mile(-1) pace were 72% less for antihypertensive, 78% less for LDL-cholesterol lowering, and 67% less for antidiabetic medications (the corresponding odds reductions in women were 61%, 64%, and 87%, respectively, for 8 min x mile(-1) or faster versus slower than 11 min x mile(-1)). Although usual running pace correlated significantly with a 10-km performance (male, r = 0.55; females, r = 0.49), usual pace remained significantly related to lower use of all three medications in men and antihypertension and antidiabetic medications in women when adjusted for a 10-km performance.
conclusionsAlthough these results do not prove causality, they show that exercise intensity is inversely associated with the prevalence of hypertension, hypercholesterolemia, and diabetes independent of exercise volume and cardiorespiratory fitness (10-km performance), suggesting that the more vigorous the exercise, the healthier the health benefits.
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Registered trials
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