ArticleProceedings of the National Academy of Sciences of the United States of America2008
A collective mechanism for phase variation in biofilms.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Contrasting genes conferring short- and long-term biofilm adaptation inMicrobial genomics · 2023Article
- Presence ofFrontiers in cellular and infection microbiology · 2021Article
- Biofilm formation on different dental restorative materials in the oral cavity.BMC oral health · 2020Article
- The small non-coding RNA RsaE influences extracellular matrix composition in Staphylococcus epidermidis biofilm communities.PLoS pathogens · 2019Article
- Interplay between Antibiotic Efficacy and Drug-Induced Lysis Underlies Enhanced Biofilm Formation at Subinhibitory Drug Concentrations.Antimicrobial agents and chemotherapy · 2018Article
- Community metabolic modeling approaches to understanding the gut microbiome: Bridging biochemistry and ecology.Free radical biology & medicine · 2017Review
- Metagenomic sequencing of marine periphyton: taxonomic and functional insights into biofilm communities.Frontiers in microbiology · 2015Article
- Islands of non-essential genes, including a DNA translocation operon, in the genome of bacteriophage 0305ϕ8-36.Bacteriophage · 2012Article
- Physiological differentiation within a single-species biofilm fueled by serpentinization.mBio · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding how microbes gather into biofilm communities and maintain diversity remains one of the central questions of microbiology, requiring an understanding of microbes as communal rather then individual organisms. Phase variation plays an integral role in the formation of diverse phenotypes within biofilms. We propose a collective mechanism for phase variation based on gene transfer agents, and apply the theory to predict the population structure and growth dynamics of a biofilm. Our results describe quantitatively recent experiments, with the only adjustable parameter being the rate of intercellular horizontal gene transfer. Our approach derives from a more general picture for the emergence of cooperation between microbes.
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Registered trials
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