ArticleMolecular biology and evolution2008
Evolutionary constraint and adaptation in the metabolic network of Drosophila.
Article in Molecular biology and evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Transcription Factors Evolve Faster Than Their Structural Gene Targets in the Flavonoid Pigment Pathway.Molecular biology and evolution · 2022Article
- Richard Dickerson, Molecular Clocks, and Rates of Protein Evolution.Journal of molecular evolution · 2021Article
- Rapid Evolution of Autosomal Binding Sites of the Dosage Compensation Complex inFrontiers in genetics · 2021Article
- Evolutionary rate variation among genes involved in galactomannan biosynthesis inEcology and evolution · 2020Article
- Gene connectivity and enzyme evolution in the human metabolic network.Biology direct · 2019Article
- Metabolic Determinants of Enzyme Evolution in a Genome-Scale Bacterial Metabolic Network.Genome biology and evolution · 2018Article
- Network Architecture and Mutational Sensitivity of theFrontiers in molecular biosciences · 2018Article
- Influence of pathway topology and functional class on the molecular evolution of human metabolic genes.PloS one · 2018Article
- Position Matters: Network Centrality Considerably Impacts Rates of Protein Evolution in the Human Protein-Protein Interaction Network.Genome biology and evolution · 2017Article
- New views on the selection acting on genetic polymorphism in central metabolic genes.Annals of the New York Academy of Sciences · 2017Review
- Positive Selection and Centrality in the Yeast and Fly Protein-Protein Interaction Networks.BioMed research international · 2016Article
- Molecular Evolution of Drosophila Germline Stem Cell and Neural Stem Cell Regulating Genes.Genome biology and evolution · 2015Article
- Constructing Metabolic Association Networks Using High-dimensional Mass Spectrometry Data.Chemometrics and intelligent laboratory systems : an international journal sponsored by the Chemometrics Society · 2014Article
- A small system--high-resolution study of metabolic adaptation in the central metabolic pathway to temperate climates in Drosophila melanogaster.Molecular biology and evolution · 2014Article
- The relationship between the hierarchical position of proteins in the human signal transduction network and their rate of evolution.BMC evolutionary biology · 2012Article
- High sensitivity to aligner and high rate of false positives in the estimates of positive selection in the 12 Drosophila genomes.Genome research · 2011Article
- Protein coalitions in a core mammalian biochemical network linked by rapidly evolving proteins.BMC evolutionary biology · 2011Article
- Expression level, cellular compartment and metabolic network position all influence the average selective constraint on mammalian enzymes.BMC evolutionary biology · 2011Article
- Article
- Molecular population genetics and selection in the glycolytic pathway.The Journal of experimental biology · 2011Review
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Authors and funding
3 authors.
Funding
Abstract
Organisms must carefully control their metabolism in order to survive. On the other hand, enzymes must adapt in response to evolutionary pressures on the pathways in which they are imbedded. Taking advantage of the newly available whole-genome sequences of 12 Drosophila species, we examined how protein function and metabolic network architecture influence rates of enzyme evolution. We found that despite high overall constraint, there were significant differences in rates of amino acid substitution among functional classes of enzymes. This heterogeneity arises because proteins involved in the metabolism of foreign compounds evolve relatively rapidly, whereas enzymes that act in "core" metabolism exhibit much slower rates of amino acid replacement, suggesting strong selective constraint. Network architecture also influences enzymes' rates of amino acid replacement. In particular, enzymes that share metabolites with many other enzymes are relatively constrained, although apparently not because they are more likely to be essential. Our analyses suggest that this pattern is driven by strong constraint of enzymes acting at branch points in metabolic pathways. We conclude that metabolic network architecture and enzyme function separately affect enzyme evolution rates.
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