ArticleGenome research2008
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Article in Genome research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
69 citing papers in PubMed, 125 citations in OpenAlex.
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- Early defects in mucopolysaccharidosis type IIIC disrupt excitatory synaptic transmission.JCI insight · 2021Article
- Differential effects by sex with Kmt5b loss.Autism research : official journal of the International Society for Autism Research · 2021Article
- Multi-scale inference of genetic trait architecture using biologically annotated neural networks.PLoS genetics · 2021Article
- EDLMFC: an ensemble deep learning framework with multi-scale features combination for ncRNA-protein interaction prediction.BMC bioinformatics · 2021Article
- Mutant non-coding RNA resource in mouse embryonic stem cells.Disease models & mechanisms · 2021Article
- Decoding pluripotency: Genetic screens to interrogate the acquisition, maintenance, and exit of pluripotency.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- LMO7 deficiency reveals the significance of the cuticular plate for hearing function.Nature communications · 2019Article
- Induction of a Long Noncoding RNA Transcript, NR_045064, Promotes Defense Gene Transcription and Facilitates Intestinal Epithelial Cell Responses againstJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- Role of metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) in pancreatic cancer.PloS one · 2018Article
- Transposons As Tools for Functional Genomics in Vertebrate Models.Trends in genetics : TIG · 2017Review
- PARTICLE triplexes cluster in the tumor suppressor WWOX and may extend throughout the human genome.Scientific reports · 2017Article
- Exome sequencing revealed a splice site variant in the IQCE gene underlying post-axial polydactyly type A restricted to lower limb.European journal of human genetics : EJHG · 2017Article
- Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain.BMC biology · 2017Article
- Comparative study of fertilization rates of C57BL/6NKorl and C57BL/6N mice obtained from two other sources.Laboratory animal research · 2017Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the construction and analysis of a mouse gene trap mutant resource created in the C57BL/6N genetic background containing more than 350,000 sequence-tagged embryonic stem (ES) cell clones. We also demonstrate the ability of these ES cell clones to contribute to the germline and produce knockout mice. Each mutant clone is identified by a genomic sequence tag representing the exact insertion location, allowing accurate prediction of mutagenicity and enabling direct genotyping of mutant alleles. Mutations have been identified in more than 10,000 genes and show a bias toward the first intron. The trapped ES cell lines, which can be requested from the Texas A&M Institute for Genomic Medicine, are readily available to the scientific community.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.