ArticleMolecular biology of the cell2008
The Sur7 protein regulates plasma membrane organization and prevents intracellular cell wall growth in Candida albicans.
Article in Molecular biology of the cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 87 citations in OpenAlex.
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- Dissecting the RNA-binding capacity of the multi-RRM protein Rrm4 essential for endosomal mRNA transport.Nucleic acids research · 2026Article
- Immunogold labeling of extracellular vesicles from the fungal pathogen Fusarium graminearum reveals the presence of the protein marker Sur7.Fungal biology and biotechnology · 2025Article
- Proximity labeling identification of plasma membrane eisosome proteins in Candida albicans.Genetics · 2025Article
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- The Cwr1 protein kinase localizes to the plasma membrane and mediates resistance to cell wall stress inmSphere · 2024Article
- Sur7 mediates a novel pathway for PIMolecular biology of the cell · 2024Article
- Article
- SUR7 deletion inJournal of extracellular biology · 2023Article
- Microdomain Protein Nce102 Is a Local Sensor of Plasma Membrane Sphingolipid Balance.Microbiology spectrum · 2022Article
- Differential Expression of Claudin in Odontogenic Cysts.European journal of dentistry · 2022Article
- The Sur7 cytoplasmic C terminus regulates morphogenesis and stress responses in Candida albicans.Molecular microbiology · 2021Article
- Plasma Membrane MCC/Eisosome Domains Promote Stress Resistance in Fungi.Microbiology and molecular biology reviews : MMBR · 2020Review
- Protein markers forJournal of extracellular vesicles · 2020Article
- The Composition and the Structure of MCC/Eisosomes inFrontiers in microbiology · 2020Article
- Extracellular vesicles from the apoplastic fungal wheat pathogenFungal biology and biotechnology · 2020Article
- Role of membrane compartment occupied by Can1 (MCC) and eisosome subdomains in plant pathogenicity of the necrotrophic fungus Alternaria brassicicola.BMC microbiology · 2019Article
- Role of MCC/Eisosome in Fungal Lipid Homeostasis.Biomolecules · 2019Review
- Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The Candida albicans plasma membrane plays important roles in cell growth and as a target for antifungal drugs. Analysis of Ca-Sur7 showed that this four transmembrane domain protein localized to stable punctate patches, similar to the plasma membrane subdomains known as eisosomes or MCC that were discovered in S. cerevisiae. The localization of Ca-Sur7 depended on sphingolipid synthesis. In contrast to S. cerevisiae, a C. albicans sur7Delta mutant displayed defects in endocytosis and morphogenesis. Septins and actin were mislocalized, and cell wall synthesis was very abnormal, including long projections of cell wall into the cytoplasm. Several phenotypes of the sur7Delta mutant are similar to the effects of inhibiting beta-glucan synthase, suggesting that the abnormal cell wall synthesis is related to activation of chitin synthase activity seen under stress conditions. These results expand the roles of eisosomes by demonstrating that Sur7 is needed for proper plasma membrane organization and cell wall synthesis. A conserved Cys motif in the first extracellular loop of fungal Sur7 proteins is similar to a characteristic motif of the claudin proteins that form tight junctions in animal cells, suggesting a common role for these tetraspanning membrane proteins in forming specialized plasma membrane domains.
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