ArticleInfection and immunity1991
Killing of Plasmodium falciparum in vitro by nitric oxide derivatives.
Article in Infection and immunity, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
79 citing papers in PubMed, 307 citations in OpenAlex.
- A comprehensive review of cerebral malaria.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Review
- Testosterone Modulates Oxidative Stress in a Sexually Dimorphic Manner in CBA/Ca Mice Infected withInternational journal of molecular sciences · 2025Article
- Studies on the mitochondrial, immunological and inflammatory effects of solvent fractions of Diospyros mespiliformis Hochst in Plasmodium berghei-infected mice.Scientific reports · 2021Article
- iNOS polymorphism modulates iNOS/NO expression via impaired antioxidant and ROS content in P. vivax and P. falciparum infection.Redox biology · 2018Article
- Cerebral malaria--clinical manifestations and pathogenesis.Metabolic brain disease · 2016Review
- The T-Cell Inhibitory Molecule Butyrophilin-Like 2 Is Up-regulated in Mild Plasmodium falciparum Infection and Is Protective During Experimental Cerebral Malaria.The Journal of infectious diseases · 2015Article
- Host immune response is severely compromised during lethal Plasmodium vinckei infection.Parasitology research · 2015Article
- S-Nitrosated Polypropylene Sulfide Nanoparticles for Thiol-Dependent Transnitrosation and Toxicity Against Adult Female Filarial Worms.Advanced healthcare materials · 2015Article
- Thiol redox biochemistry: insights from computer simulations.Biophysical reviews · 2014Review
- Experimental Models of Microvascular Immunopathology: The Example of Cerebral Malaria.Journal of neuroinfectious diseases · 2014Article
- Immunomodulatory effects of recombinant BCG expressing MSP-1C of Plasmodium falciparum on LPS- or LPS+IFN-γ-stimulated J774A.1 cells.Human vaccines & immunotherapeutics · 2014Article
- Article
- Hemoglobinopathies: slicing the Gordian knot of Plasmodium falciparum malaria pathogenesis.PLoS pathogens · 2013Review
- S-nitrosoglutathione prevents experimental cerebral malaria.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Article
- Review
- Polysaccharides from the Chinese medicinal herb Achyranthes bidentata enhance anti-malarial immunity during Plasmodium yoelii 17XL infection in mice.Malaria journal · 2012Article
- Nitric oxide for the adjunctive treatment of severe malaria: hypothesis and rationale.Medical hypotheses · 2011Article
- Nitric oxide and redox mechanisms in the immune response.Journal of leukocyte biology · 2011Review
- Parasite killing in malaria non-vector mosquito Anopheles culicifacies species B: implication of nitric oxide synthase upregulation.PloS one · 2011Article
- Nitric oxide is involved in the upregulation of IFN-γ and IL-10 mRNA expression by CD8⁺ T cells during the blood stages of P. chabaudi AS infection in CBA/Ca mice.International journal of biological sciences · 2011Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have investigated the in vitro susceptibility of the human malaria parasite Plasmodium falciparum to killing by nitric oxide and related molecules. A saturated solution of nitric oxide did not inhibit parasite growth, but two oxidation products of nitric oxide (nitrite and nitrate ions) were toxic to the parasite in millimolar concentrations. Nitrosothiol derivatives of cysteine and glutathione were found to be about a thousand times more active (50% growth inhibitory concentration, approximately 40 microM) than nitrite.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.