Evidence map›Paper›PMID 18799144›Full record

ReviewImmunity2008

Tuning microenvironments: induction of regulatory T cells by dendritic cells.

Yasmine Belkaid, Guillaume Oldenhove

Abstract readReview
In one paragraph

Review in Immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Tuberculosis and Autoimmunity.Pathophysiology : the official journal of the International Society for Pathophysiology · 2022
    Review
  11. Article
  12. The yin/yang balance of the MHC-selfFrontiers in immunology · 2022
    Review
  13. Article
  14. Review
  15. Review
  16. Deletion Mutants ofPathogens (Basel, Switzerland) · 2021
    Article
  17. Article
  18. Article
  19. Review
  20. Review

59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yasmine BelkaidMucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20894, USA.
Guillaume Oldenhove

Funding

Role of the microbiota in immunityZIAAI001115 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BELKAID, YASMINE · 2009 to 2025
$22.4M
Role of Regulatory T Cells in Parasitic InfectionsZIAAI000955 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BELKAID, YASMINE · 2009 to 2010
$1.6M
Role of Gut-Specific Factors in the Control of Regulatory T CellsZ01AI001061 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BELKAID, YASMINE · 2008 to 2008
$952k
Intramural NIH HHS Z01 AI001061
6 · The paper itself

Abstract

The body requires the generation of regulatory T (Treg) cells to preserve its integrity. Each microenvironment is controlled by a specific set of regulatory elements that have to be finefrly and constantly tuned to maintain local homeostasis. These environments could be site specific, such as the gut environment, or induced by chronic exposure to microbes or tumors. Various populations of dendritic cells (DCs) are central to the orchestration of this control. In this review, we will discuss some new findings associating DCs from defined compartments with the induction of antigen-specific Treg cells.

Indexed as

AnimalsAntigen PresentationCell CommunicationCell DifferentiationCytokinesDendritic CellsForkhead Transcription FactorsHumansImmune ToleranceInfectionsLymphocyte ActivationT-Lymphocytes, RegulatoryCytokinesForkhead Transcription Factors

Identifiers

PMID18799144
PMCPMC3415213

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.