Evidence map›Paper›PMID 18799141›Full record

ReviewImmunity2008

Mechanisms and consequences of dendritic cell migration.

David Alvarez, Elisabeth H Vollmann, Ulrich H von Andrian

Open access · bronzeAbstract readReview
In one paragraph

Review in Immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 249 papers.

0numbers the graph read from it
0cells of the map it votes in
249citing papers in PubMed
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

249 citing papers in PubMed, 525 citations in OpenAlex.

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  13. bioRxiv : the preprint server for biology · 2025
    Article
  14. Weak and Tunable Adhesion-Clutch Drives Rapid Cell Migration and Glioblastoma Invasion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
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189 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

David AlvarezDepartment of Pathology, Harvard Medical School, Boston, MA 02115, USA.
Elisabeth H Vollmann
Ulrich H von Andrian
Harvard University · US

Funding

PREVENTION OF COLD INDUCED PLATELET STORAGE LESIONP01HL056949 · NHLBI · IMMUNE DISEASE INSTITUTE, INC. · PI WAGNER, DENISA D · 1996 to 2010
$26.2M
Visualizing Effects of Costimulation on Antiviral ImmunityP01AI078897 · NIAID · HARVARD MEDICAL SCHOOL · PI VON ANDRIAN, ULRICH H · 2008 to 2012
$12.1M
T Cell Activation in Lymph NodesR01AI069259 · NIAID · IMMUNE DISEASE INSTITUTE, INC. · PI VON ANDRIAN, ULRICH H · 2006 to 2015
$4.5M
Differentiation and Regulation of CTLR01AI072252 · NIAID · HARVARD MEDICAL SCHOOL · PI VON ANDRIAN, ULRICH H · 2007 to 2011
$2.1M
NHLBI NIH HHS P01 HL056949NHLBI NIH HHS P01 HL56949NIAID NIH HHS P01 AI078897NIAID NIH HHS R01 AI069259NIAID NIH HHS R01 AI072252
6 · The paper itself

Abstract

Dendritic cells (DCs) are critical for adaptive immunity and tolerance. Most DCs are strategically positioned as immune sentinels poised to respond to invading pathogens in tissues throughout the body. Differentiated DCs and their precursors also circulate in blood and can get rapidly recruited to sites of challenge. Within peripheral tissues, DCs collect antigenic material and then traffic to secondary lymphoid organs, where they communicate with lymphocytes to orchestrate adaptive immune responses. Hence, the migration and accurate positioning of DCs is indispensable for immune surveillance. Here, we review the molecular traffic signals that govern the migration of DCs throughout their life cycle.

Indexed as

Cell MovementChemotaxisAnimalsChemotactic FactorsCytokinesDendritic CellsHumansLymphoid TissueReceptors, ChemokineSignal TransductionSpleenChemotactic FactorsCytokinesReceptors, Chemokine

Identifiers

PMID18799141
PMCPMC2818978
OpenAlexW1967415740

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.