ArticleMethods (San Diego, Calif.)2009
Parthenogenesis-derived multipotent stem cells adapted for tissue engineering applications.
Article in Methods (San Diego, Calif.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Directing the Differentiation of Parthenogenetic Stem Cells into Tenocytes for Tissue-Engineered Tendon Regeneration.Stem cells translational medicine · 2017Article
- Directing parthenogenetic stem cells differentiate into adipocytes for engineering injectable adipose tissue.Stem cells international · 2014Article
- Telomere elongation in parthenogenetic stem cells.Protein & cell · 2014Article
- Bioactive polymer scaffold for fabrication of vascularized engineering tissue.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2012Review
- Transcriptome profiling of rabbit parthenogenetic blastocysts developed under in vivo conditions.PloS one · 2012Article
- Germline competency of parthenogenetic embryonic stem cells from immature oocytes of adult mouse ovary.Human molecular genetics · 2011Article
- From embryonic stem cells to iPS - an ethical perspective.Cell proliferation · 2011Article
- Current protocols in the generation of pluripotent stem cells: theoretical, methodological and clinical considerations.Stem cells and cloning : advances and applications · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Embryonic stem cells are envisioned as a viable source of pluripotent cells for use in regenerative medicine applications when donor tissue is not available. However, most current harvest techniques for embryonic stem cells require the destruction of embryos, which has led to significant political and ethical limitations on their usage. Parthenogenesis, the process by which an egg can develop into an embryo in the absence of sperm, may be a potential source of embryonic stem cells that may avoid some of the political and ethical concerns surrounding embryonic stem cells. Here we provide the technical aspects of embryonic stem cell isolation and expansion from the parthenogenetic activation of oocytes. These cells were characterized for their stem-cell properties. In addition, these cells were induced to differentiate to the myogenic, osteogenic, adipogenic, and endothelial lineages, and were able to form muscle-like and bony-like tissue in vivo. Furthermore, parthenogenetic stem cells were able to integrate into injured muscle tissue. Together, these results demonstrate that parthenogenetic stem cells can be successfully isolated and utilized for various tissue engineering applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.