ArticleExperimental gerontology2008
The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration.
Article in Experimental gerontology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis.Aging cell · 2025Pooled it
- NMN Alleviates NP-Induced Learning and Memory Impairment Through SIRT1 Pathway in PC-12 Cell.Molecular neurobiology · 2023Article
- Severity Level and Duration of Energy Deficit in Mice Affect Bone Phenotype and Bone Marrow Stromal Cell Differentiation Capacity.Frontiers in endocrinology · 2022Article
- Recovery of Olfactory Function After Excitotoxic Lesion of the Olfactory Bulbs Is Associated with Increases in Bulbar SIRT1 and SIRT4 Expressions.Molecular neurobiology · 2019Article
- Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure.CNS neuroscience & therapeutics · 2019Review
- Sirtuins in Neuroendocrine Regulation and Neurological Diseases.Frontiers in neuroscience · 2018Review
- Antinociceptive effects of caloric restriction on post-incisional pain in nonobese rats.Scientific reports · 2017Article
- Emerging Molecular Pathways Governing Dietary Regulation of Neural Stem Cells during Aging.Frontiers in physiology · 2017Review
- Treatment of SMB-S15 Cells with Resveratrol Efficiently Removes the PrP(Sc) Accumulation In Vitro and Prion Infectivity In Vivo.Molecular neurobiology · 2016Article
- Epigenetic alterations in the suprachiasmatic nucleus and hippocampus contribute to age-related cognitive decline.Oncotarget · 2015Review
- Scrapie infection in experimental rodents and SMB-S15 cells decreased the brain endogenous levels and activities of Sirt1.Journal of molecular neuroscience : MN · 2015Article
- Non-coding RNA in neural function, disease, and aging.Frontiers in genetics · 2015Review
- Role of Sirt1 during the ageing process: relevance to protection of synapses in the brain.Molecular neurobiology · 2014Review
- SIRT1 in neurodevelopment and brain senescence.Neuron · 2014Review
- Neurodegenerative disease and obesity: what is the role of weight loss and bariatric interventions?Metabolic brain disease · 2013Review
- A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- SIRT1 and SIRT2: emerging targets in neurodegeneration.EMBO molecular medicine · 2013Review
- Effects of diet on synaptic vesicle release in dynactin complex mutants: a mechanism for improved vitality during motor disease.Aging cell · 2012Article
- Sirtuin biology and relevance to diabetes treatment.Diabetes management (London, England) · 2012Article
- Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy.The Journal of experimental medicine · 2012Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
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Abstract
A central focus of aging research is to determine how calorie restriction (CR) extends lifespan and delays diseases of aging. SIRT1, the mammalian ortholog of Sir2 in yeast, is a longevity factor which mediates dietary restriction in diverse species. In addition, SIRT1 plays a protective role in several models of neurodegenerative disease. We tested the role of SIRT1 in mediating the effects of CR in a mouse model of prion disease. Prion diseases are protein misfolding disorders of the central nervous system with many similarities to other neurodegenerative diseases, including deposition of aggregated protein, gliosis, and loss of synapses and neurons. We report that the onset of prion disease is delayed by CR and in the SIRT1 KO mice fed ad libitum. CR exerts no further effect on the SIRT1 KO strain, suggesting the effects of CR and SIRT1 deletion are mechanistically coupled. In conjunction, SIRT1 is downregulated in certain brain regions of CR mice. The expression of PrP mRNA and protein is reduced in the brains of CR mice and in SIRT1 knockout mice, suggesting a possible mechanism for the delayed onset of disease, as PrP levels are a critical determinant of how quickly mice succumb to prion disease. Surprisingly, CR greatly shortens the duration of clinical symptoms of prion disease and ultimately shortens lifespan of prion-inoculated mice in a manner that is independent of SIRT1. Taken together, our results suggest a more complex interplay between CR, SIRT1, and neurodegenerative diseases than previously appreciated.
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Registered trials
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