ReviewCurrent gastroenterology reports2008
A roadmap for understanding and preventing necrotizing enterocolitis.
Review in Current gastroenterology reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01735578 (Splanchnic Tissue Oxygenation During Enteral Feedings in Anemic Premature Infants at Risk for Necrotizing Enterocolitis), which is not on this map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Splanchnic Tissue Oxygenation During Enteral Feedings in Anemic Premature Infants at Risk for Necrotizing Enterocolitis
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Comparative efficacy of different single drugs to prevent necrotizing enterocolitis in preterm infants: an update systematic review and network meta-analysis.Frontiers in nutrition · 2024Pooled it
- Necrotizing Enterocolitis in Preterm Infants: An Inflammatory Condition at the Crossroads of Intestinal Immaturity, Dysbiosis, and Nutrition.International journal of pediatrics · 2026Review
- Longitudinal Fecal Short-Chain Fatty Acid Trajectories in Preterm Infants with Early-Onset Neonatal Sepsis: A Pilot Study.Life (Basel, Switzerland) · 2025Article
- Development and validation of a nomogram for predicting necrotizing enterocolitis in premature infants with early-onset sepsis.Scientific reports · 2025Article
- An early post-birth immune-microbiota landscape predicts the development of necrotizing enterocolitis in term newborns with congenital heart defects.Scientific reports · 2025Article
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- Article
- Reduced Gut Bacterial Diversity in Early Life Predicts Feeding Intolerance in Preterm Neonates.Tropical medicine and infectious disease · 2024Article
- Impact of fetal inflammatory response on the severity of necrotizing enterocolitis in preterm infants.Pediatric research · 2024Article
- Reduction in regulatory T cells in preterm newborns is associated with necrotizing enterocolitis.Pediatric research · 2023Article
- Longitudinal observational study protocol - Preterm Infants: Microbiome Establishment, Neuro-CrossTalk and Origins (PIMENTO).BMJ open · 2023Article
- Influence of Perinatal Factors on Blood Tryptase and Fecal Calprotectin Levels in Newborns.Children (Basel, Switzerland) · 2023Article
- Analyzing the Complicated Connection Between Intestinal Microbiota and Cardiovascular Diseases.Cureus · 2022Review
- Clinical implications of preterm infant gut microbiome development.Nature microbiology · 2022Article
- Surfactant protein A reduces TLR4 and inflammatory cytokine mRNA levels in neonatal mouse ileum.Scientific reports · 2021Article
- Comparison of Necrotizing Enterocolitis in Pre-mature Infants vs. Term-Born Infants With Congenital Heart Disease.Frontiers in pediatrics · 2021Article
- Lysosomal overloading and necrotizing enterocolitis.Pediatric surgery international · 2020Article
- The fetal inflammatory response syndrome: the origins of a concept, pathophysiology, diagnosis, and obstetrical implications.Seminars in fetal & neonatal medicine · 2020Article
- Necrotizing enterocolitis: It's not all in the gut.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Ghrelin ameliorates the phenotype of newborn rats induced with mild necrotizing enterocolitis.Neurogastroenterology and motility · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Necrotizing enterocolitis (NEC) is the most common severe gastrointestinal emergency that affects newborns. Its etiology is still undetermined. Most of our knowledge of this disease stems from epidemiologic studies, clinical experience, and studies using animal models that do not directly represent the disease in premature infants. An immature intestine that is colonized by bacteria is a prerequisite for the pathogenesis of NEC. Although causative microbes have not been found, newly developed analytic techniques now allow the detection of noncultivatable microbes and the determination of their overall diversity and metabolic capabilities. The National Institutes of Health Human Microbiome Roadmap Project is likely to generate new information highly germane to understanding NEC. Newly developed proteomic and metabolomic approaches also offer exciting new potential for early diagnosis and prevention of this disease in infants at highest risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.