ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2009
Osteomyelitis of the jaw: resistance to clindamycin in patients with prior antibiotics exposure.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 38 citations in OpenAlex.
- Involvement of resistant bacteria in the severity of refractory osteonecrosis of the jaw.Clinical oral investigations · 2025Article
- Swabs versus native specimens in severe head and neck infections: a prospective pilot study and suggestions for clinical management.Oral and maxillofacial surgery · 2025Article
- Is Penicillin Allergy a Risk Factor for Early Dental Implant Failure? A Systematic Review.Antibiotics (Basel, Switzerland) · 2021Review
- Development of osteomyelitis following dental abscesses-influence of therapy and comorbidities.Clinical oral investigations · 2021Article
- Calculated parenteral initial treatment of bacterial infections: Infections in the ear, nose, throat and mouth and jaw area.GMS infectious diseases · 2020Article
- Risk factors of recurrence and life-threatening complications for patients hospitalized with chronic suppurative osteomyelitis of the jaw.BMC infectious diseases · 2013Article
- Phase composition control of calcium phosphate nanoparticles for tunable drug delivery kinetics and treatment of osteomyelitis. II. Antibacterial and osteoblastic response.Journal of biomedical materials research. Part A · 2013Article
- An unreported clindamycin adverse reaction: wrist monoarthritis.Iranian journal of pharmaceutical research : IJPR · 2012Article
- Surgical management of primary chronic osteomyelitis of the jaws in children: a prospective analysis of five cases and review of the literature.Oral and maxillofacial surgery · 2011Review
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7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this paper was to review our clinical experience in patients with osteomyelitis (OM) of the jaw, focusing on aspects of antimicrobial resistance. A retrospective review of the medical records of adult patients with jaw OM was carried out. Among 46 cases of jaw OM, the cause was odontogenic in 32 (seven had recent dental implants and four bisphosphonate osteonecrosis), postoperative/post-traumatic in eight, and secondary to osteoradionecrosis in six. Clinical features were chronic in 91.3%. The infection was polymicrobial in 24/41 (65.9%). Viridans streptococci were the most commonly isolated agents. Among 26 viridans streptococci tested, 81% were susceptible to penicillin and 96% to fluorquinolones, but only 11.5% to clindamycin. Overall, 35/38 (92.1%) had at least one clindamycin-resistant isolate. Appropriate antibiotics were administered for a mean of 5.8 +/- 3.2 months. Beta-lactams were used in 19 cases and fluorquinolones in 14. Among 39 cases with long-term follow-up, only two relapsed. Currently, jaw OM is commonly related to osteoradionecrosis, dental implants, and bisphosphonates. In patients with prior antibiotics exposure, a high percentage of infections were caused by clindamycin-resistant microorganisms, thus, beta-lactams should be the antibiotic of choice. In penicillin-allergic cases, the new fluorquinolones, probably in combination with rifampin and/or clindamycin, could be a promising alternative.
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