ReviewPediatric nephrology (Berlin, Germany)2010
Nephrocalcinosis in preterm neonates.
Review in Pediatric nephrology (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Vitamin D supplementation for prevention of vitamin D deficiency in preterm and low birth weight infants.The Cochrane database of systematic reviews · 2026Pooled it
- Calcium and phosphorus supplementation of human milk for preterm infants.The Cochrane database of systematic reviews · 2017Pooled it
- Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial.Nutrients · 2021Trial
- Trial
- Molecular and Genetic Determinants of Nephrocalcinosis: Mechanisms, Genotype-Phenotype Correlations, and Precision Medicine.International journal of molecular sciences · 2026Review
- Incidence, risk factors, and outcomes of nephrocalcinosis in preterm infants: a prospective cohort study.Pediatric nephrology (Berlin, Germany) · 2025Observational
- Clinical characteristics of nephrocalcinosis in a tertiary children's hospital.Frontiers in pediatrics · 2025Article
- A Prospective Study of Nephrocalcinosis in Very Preterm Infants: Incidence, Risk Factors and Vitamin D Intake in the First Month.Medicina (Kaunas, Lithuania) · 2024Observational
- Bilateral Global Nephrocalcinosis in a Uremic Puppy.Veterinary sciences · 2024Article
- Article
- Etiology and prognosis of nephrocalcinosis according to gestational age in Korean children.BMC pediatrics · 2023Article
- Article
- Hypervitaminosis D and nephrocalcinosis: too much of a good thing?Pediatric nephrology (Berlin, Germany) · 2022Article
- Vitamin D, bone density, and nephrocalcinosis in preterm infants: a prospective study.Pediatric nephrology (Berlin, Germany) · 2022Observational
- Nephrolithiasis during the first 6 months of life in exclusively breastfed infants.Pediatric nephrology (Berlin, Germany) · 2021Article
- Update on Calcium and Phosphorus Requirements of Preterm Infants and Recommendations for Enteral Mineral Intake.Nutrients · 2021Review
- Prematurity and Low Birth Weight in Neonates as a Risk Factor for Obesity, Hypertension, and Chronic Kidney Disease in Pediatric and Adult Age.Frontiers in medicine · 2021Review
- Nephrocalcinosis and Renal Dysfunction in Pediatric Intestinal Failure.Journal of pediatric gastroenterology and nutrition · 2020Article
- Furosemide use in Italian neonatal intensive care units: a national survey.Italian journal of pediatrics · 2020Article
- Infantile Nephrocalcinosis Resulting From a Pathogenic CYP24A1 Mutation.Kidney international reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of nephrocalcinosis (NC) in preterm neonates in recent reports is 7-41%. The wide range in prevalence is a consequence of different study populations and ultrasound equipment and criteria, in addition to a moderate interobserver variation. NC in preterm neonates has a multifactorial aetiology, consisting of low gestational age and birth weight, often in combination with severe respiratory disease, and occurs as a result of an imbalance between stone-promoting and stone-inhibiting factors. A limited number of histological studies suggest that calcium oxalate crystals play an important role in NC in premature neonates. In 85% of children resolution of NC occurs in the first years of life. Prematurity, per se, is associated with high blood pressure, relatively small kidneys, and (distal) tubular dysfunction. In addition, NC in preterm neonates can have long-term sequelae for glomerular and tubular function. Long-term follow-up of blood pressure and renal function of prematurely born children, especially with neonatal NC, is recommended. Prevention of NC with (low) oral doses of citrate has not resulted in a significant decrease in the prevalence of NC; a higher citrate dosage deserves further study. Future research pertaining to prevention of NC in preterm neonates is crucial.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.