ArticleDevelopment genes and evolution2008
Comprehensive survey and classification of homeobox genes in the genome of amphioxus, Branchiostoma floridae.
Article in Development genes and evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed, 80 citations in OpenAlex.
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- Single-cell Transcriptomic Studies Unveil Potential Nodes of the Notochord Gene Regulatory Network.Integrative and comparative biology · 2024Review
- Evolutionary origin of the chordate nervous system revealed by amphioxus developmental trajectories.Nature ecology & evolution · 2024Article
- Evolution of Telencephalon Anterior-Posterior Patterning through Core Endogenous Network Bifurcation.Entropy (Basel, Switzerland) · 2024Article
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- Genome of the ramshorn snail Biomphalaria straminea-an obligate intermediate host of schistosomiasis.GigaScience · 2022Article
- The dorsoanterior brain of adult amphioxus shares similarities in expression profile and neuronal composition with the vertebrate telencephalon.BMC biology · 2021Article
- Expression of NK genes that are not part of the NK cluster in the onychophoran Euperipatoides rowelli (Peripatopsidae).BMC developmental biology · 2019Article
- Sponges Lack ParaHox Genes.Genome biology and evolution · 2019Article
- Comparative genomics reveals the distinct evolutionary trajectories of the robust and complex coral lineages.Genome biology · 2018Article
- Xenacoelomorpha Survey Reveals That All 11 Animal Homeobox Gene Classes Were Present in the First Bilaterians.Genome biology and evolution · 2018Article
- A Revised Spiralian Homeobox Gene Classification Incorporating New Polychaete Transcriptomes Reveals a Diverse TALE Class and a Divergent Hox Gene.Genome biology and evolution · 2018Article
- Pax3/7 duplicated and diverged independently in amphioxus, the basal chordate lineage.Scientific reports · 2018Article
- De novo draft assembly of the Botrylloides leachii genome provides further insight into tunicate evolution.Scientific reports · 2018Article
- Expression of NK cluster genes in the onychophoranEvoDevo · 2018Article
- Multifunctional glial support by Semper cells in the Drosophila retina.PLoS genetics · 2017Article
- Hox gene cluster of the ascidian,Zoological letters · 2017Article
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Authors and funding
7 authors at 4 institutions in 3 countries.
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Abstract
The homeobox genes comprise a large and diverse gene superfamily, many of which encode transcription factors with pivotal roles in the embryonic development of animals. We searched the assembled draft genome sequence of an amphioxus, Branchiostoma floridae, for genes possessing homeobox sequences. Phylogenetic analysis was used to divide these into gene families and classes. The 133 amphioxus homeobox genes comprise 60 ANTP class genes, 29 PRD genes (excluding Pon and Pax1/9), nine TALE genes, seven POU genes, seven LIM genes, five ZF genes, four CUT genes, four HNF genes, three SINE genes, one CERS gene, one PROS gene, and three unclassified genes. Ten of the 11 homeobox gene classes are less diverse in amphioxus than humans, as a result of gene duplication on the vertebrate lineage. Amphioxus possesses at least one member for all of the 96 homeobox gene families inferred to be present in the common ancestor of chordates, including representatives of the Msxlx, Bari, Abox, Nk7, Ro, and Repo gene families that have been lost from tunicates and vertebrates. We find duplication of several homeobox genes in the cephalochordate lineage (Mnx, Evx, Emx, Vent, Nk1, Nedx, Uncx, Lhx2/9, Hmbox, Pou3, and Irx) and several divergent genes that probably originated by extensive sequence divergence (Hx, Ankx, Lcx, Acut, Atale, Azfh, Ahbx, Muxa, Muxb, Aprd1-6, and Ahnf). The analysis reveals not only the repertoire of amphioxus homeobox genes but also gives insight into the evolution of chordate homeobox genes.
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