ArticleImmunogenetics2008
Ovine progressive pneumonia provirus levels associate with breed and Ovar-DRB1.
Article in Immunogenetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 63 citations in OpenAlex.
- First Report of SNPs Detection in TMEM154 Gene in Sheep from Poland and Their Association with SRLV Infection Status.Pathogens (Basel, Switzerland) · 2024Article
- Cross-Sectional Study Assessing Management Practices and Udder Health in California Sheep Flocks and Seroprevalence of Small Ruminant Lentivirus.Animals : an open access journal from MDPI · 2024Article
- Emergence and pandemic spread of small ruminant lentiviruses.Virus evolution · 2023Article
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- Impact of Four OvineInternational journal of molecular sciences · 2022Article
- Molecular Characterization of Small Ruminant Lentiviruses Isolated from Polish Goats with Arthritis.Viruses · 2022Article
- Association of Ovar-DRB1 alleles with innate immune responses in sheep.Veterinary medicine and science · 2022Article
- A high-density genome-wide association with absolute blood monocyte count in domestic sheep identifies novel loci.PloS one · 2022Article
- Transcriptome Analysis for Genes Associated with Small Ruminant Lentiviruses Infection in Goats of Carpathian Breed.Viruses · 2021Article
- A novel 2 bp deletion variant in Ovine-DRB1 gene is associated with increased Visna/maedi susceptibility in Turkish sheep.Scientific reports · 2021Article
- Single Nucleotide Polymorphisms in Genes Encoding Toll-Like Receptors 7 and 8 and Their Association with Proviral Load of SRLVs in Goats of Polish Carpathian Breed.Animals : an open access journal from MDPI · 2021Article
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- Article
- Both candidate gene and neutral genetic diversity correlate with parasite resistance in female Mediterranean mouflon.BMC ecology · 2019Article
- Genetic diversity ofJournal of genetics · 2018Article
- First survey on association of TMEM154 and CCR5 variants with serological maedi-visna status of sheep in German flocks.Veterinary research · 2018Article
- Mutations in Ovis aries TMEM154 are associated with lower small ruminant lentivirus proviral concentration in one sheep flock.Animal genetics · 2014Article
- Deletion variant near ZNF389 is associated with control of ovine lentivirus in multiple sheep flocks.Animal genetics · 2014Article
- MHC-DRB1/DQB1 Gene Polymorphism and Its Association with Resistance/Susceptibility to Cystic Echinococcosis in Chinese Merino Sheep.Journal of parasitology research · 2014Article
- Retroviral infections in sheep and goats: small ruminant lentiviruses and host interaction.Viruses · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies initiated defining the role of host genetics in influencing the outcome of exposure to ovine progressive pneumonia virus. However, specific genes influencing host control of virus replication and disease progression have not been identified. This study, using 383 ewes of the Columbia, Polypay, and Rambouillet breeds, tested the hypothesis that host control of OPPV as measured by provirus levels in the peripheral blood associates with certain breeds and MHC class II Ovis aries (Ovar)-DRB1 expressed alleles. Rambouillet ewes were less likely to have measurable provirus levels as compared to Columbia ewes at ages 5 and 6 (P value < 0.02), and they exhibited lower provirus levels when compared to both Columbia and Polypay ewes of the same ages (P value < 0.05). The presence of DRB1*0403- or DRB1*07012-expressed alleles were significantly associated (P value = 0.019 and 0.0002, respectively) with lower OPP provirus levels but only were only found in 11% of the ewe flock. Analysis of each segregating amino acid in the beta1 domain of DR beta-chain revealed that amino acids Y31, T32, N37, T51, Q60, or N74 significantly associated (P value range = 0.0003-0.018) with lower OPP provirus levels, whereas amino acids H32, A38, or I67 associated (P value range = 0.013-0.043) with higher OPP provirus levels. These results suggest that Ovar-DRB1 contributes as one host genetic factor that controls OPP provirus levels, but does not fully account for the breed-specific OPP proviral differences.
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