Evidence map›Paper›PMID 18797645›Full record

ArticleBulletin of the World Health Organization2008

Declining HIV prevalence among young pregnant women in Lusaka, Zambia.

Elizabeth M Stringer, Namwinga T Chintu, Jens W Levy, Moses Sinkala, Benjamin H Chi, Jubra Muyanga, Marc Bulterys, Maximilian Bweupe, Karen Megazzini, Jeffrey S A Stringer

Open access · diamondAbstract read
In one paragraph

Article in Bulletin of the World Health Organization, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
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  14. Optimal time on HAART for prevention of mother-to-child transmission of HIV.Journal of acquired immune deficiency syndromes (1999) · 2011
    Article
  15. Article
  16. Implementation of the Zambia electronic perinatal record system for comprehensive prenatal and delivery care.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2011
    Article
  17. Modern contraceptive and dual method use among HIV-infected women in Lusaka, Zambia.Infectious diseases in obstetrics and gynecology · 2011
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Elizabeth M StringerDepartment of Obstetrics and Gynecology, University of Alabama, Birmingham, AL, United States of America. eli@uab.edu
Namwinga T Chintu
Jens W Levy
Moses Sinkala
Benjamin H Chi
Jubra Muyanga
Marc Bulterys
Maximilian Bweupe
Karen Megazzini
Jeffrey S A Stringer
University of Alabama at Birmingham Hospital · US

Funding

Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1M
Career Development Award in International Women's HealthK01TW005708 · FIC · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STRINGER, ELIZABETH MCPHILLIPS · 2001 to 2005
$549k
A Training Program in International Women's HealthK01TW006670 · FIC · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHI, BENJAMIN H. · 2005 to 2009
$512k
FIC NIH HHS K01 TW005708FIC NIH HHS K01 TW006670FIC NIH HHS K01-TW05708FIC NIH HHS K01-TW06670NIAID NIH HHS P30 AI027767NIAID NIH HHS P30-AI027767PHS HHS U62/CCU12354
6 · The paper itself

Abstract

objectiveHIV prevention has been ongoing in Lusaka for many years. Recent reports suggest a possible decline in HIV sero-incidence in Zambia and some neighbouring countries. This study aimed to examine trends in HIV seroprevalence among pregnant and parturient women between 2002 and 2006.

methodsWe analysed HIV seroprevalence trends from two Lusaka sources: (i) antenatal data from a city-wide programme to prevent mother-to-child HIV transmission, and (ii) delivery data from two anonymous unlinked cord-blood surveillances performed in 2003 and again in 2005-2006, where specimens from > 97% of public-sector births in each period were obtained and analysed.

findingsBetween July 2002 and December 2006, the Lusaka district tested 243 302 antenatal women for HIV; 54 853 (22.5%) were HIV infected. Over this period, the HIV seroprevalence among antenatal attendees who were tested declined steadily from 24.5% in the third quarter of 2002 to 21.4% in the last quarter of 2006 (P < 0.001). The cord-blood surveillances were conducted between June and August 2003 and again between October 2005 and January 2006. Overall HIV seroprevalence declined from 25.7% in 2003 to 21.8% in 2005-2006 (P = 0.001). Among women < or =17 years of age, seroprevalence declined from 12.1% to 7.7% (P = 0.015).

conclusionHIV seroprevalence appears to be declining among antenatal and parturient women in Lusaka. The decline is most dramatic among women < or = 17 years of age, suggesting a reduction in sero-incidence in this important age group.

Indexed as

AdolescentAdultFemaleFetal BloodHIV SeroprevalenceHumansPregnancyPregnancy Complications, InfectiousPrevalenceYoung AdultZambia

Identifiers

PMID18797645
PMCPMC2649483
OpenAlexW2132108699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.