ArticleACS nano2007
Multiple lipid compartments slow vesicle contents release in lipases and serum.
Article in ACS nano, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Emerging Trends in Lipid-Based Vaccine Delivery: A Special Focus on Developmental Strategies, Fabrication Methods, and Applications.Vaccines · 2023Review
- Unraveling multilayered extracellular vesicles: Speculation on cause.Journal of extracellular vesicles · 2023Article
- Liposome-Tethered Gold Nanoparticles Triggered by Pulsed NIR Light for Rapid Liposome Contents Release and Endosome Escape.Pharmaceutics · 2022Review
- Synthetic cells in biomedical applications.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2022Review
- pH-Triggered Assembly of Endomembrane Multicompartments in Synthetic Cells.ACS synthetic biology · 2022Article
- USE OF ARTIFICIAL CELLS AS DRUG CARRIERS.Materials chemistry frontiers · 2021Article
- Fluorescent Lipo-Beads for the Sensitive Detection of Phospholipase AACS biomaterials science & engineering · 2020Article
- Near Infrared-Triggered Liposome Cages for Rapid, Localized Small Molecule Delivery.Scientific reports · 2020Article
- Toward Functional Synthetic Cells: In-Depth Study of Nanoparticle and Enzyme Diffusion through a Cross-Linked Polymersome Membrane.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Perfluoroheptane-Loaded Hollow Gold Nanoshells Reduce Nanobubble Threshold Flux.Small (Weinheim an der Bergstrasse, Germany) · 2019Article
- Synthetic beta cells for fusion-mediated dynamic insulin secretion.Nature chemical biology · 2018Article
- Multivesicular droplets: a cell model system to study compartmentalised biochemical reactions.Lab on a chip · 2017Article
- Glucosomes: Glycosylated Vesicle-in-Vesicle Aggregates in Water from pH-Responsive Microbial Glycolipid.ChemistryOpen · 2017Article
- High-intensity focused ultrasound-triggered nanoscale bubble-generating liposomes for efficient and safe tumor ablation under photoacoustic imaging monitoring.International journal of nanomedicine · 2017Article
- Inside-outside self-assembly of light-activated fast-release liposomes.Physical chemistry chemical physics : PCCP · 2015Article
- Rapid, Reversible Release from Thermosensitive Liposomes Triggered by Near-Infra-Red Light.Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems · 2014Article
- Cross-linkable liposomes stabilize a magnetic resonance contrast-enhancing polymeric fastener.Langmuir : the ACS journal of surfaces and colloids · 2014Article
- Automated formation of multicomponent-encapuslating vesosomes using continuous flow microcentrifugation.Biotechnology journal · 2013Article
- Precise quantification of nanoparticle internalization.ACS nano · 2013Article
- Transcutaneous antigen delivery system.BMB reports · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Unilamellar vesicles or "liposomes" are commonly used as simple cell models and as drug delivery vehicles. A major limitation of unilamellar liposomes in these applications has been premature contents release in physiological environments. This premature release is likely due to enzyme degradation or protein insertion into the liposome membrane, which significantly increases the bilayer permeability. Encapsulating unilamellar liposomes within a second bilayer to form multicompartment "vesosomes" extends contents retention by 2 orders of magnitude by preventing enzymes and/or proteins from reaching the interior bilayers. The multicompartment structure of the vesosome can also allow for independent optimization of the interior compartments and exterior bilayer; however, just the bilayer-within-a-bilayer structure of the vesosome is sufficient to increase drug retention from minutes to hours. The vesosome is a better mimic of eukaryotic cell structure and demonstrates the benefits of multiple internal bilayer-enclosed compartments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.