ArticleInternational journal of medical sciences2008
TMZ-BioShuttle--a reformulated temozolomide.
Article in International journal of medical sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- NIR-Cyanine Dye Linker: a Promising Candidate for Isochronic Fluorescence Imaging in Molecular Cancer Diagnostics and Therapy Monitoring.Theranostics · 2016Article
- A peptide & peptide nucleic acid synthesis technology for transporter molecules and theranostics--the SPPS.International journal of medical sciences · 2014Article
- SPPS resins impact the PNA-syntheses' improvement.International journal of medical sciences · 2013Article
- Improved synthesis strategy for peptide nucleic acids (PNA) appropriate for cell-specific fluorescence imaging.International journal of medical sciences · 2012Article
- Synthesis and evaluation of a series of 1,2,4,5-tetrazines for bioorthogonal conjugation.Bioconjugate chemistry · 2011Article
- Enhancement of the click chemistry for the inverse Diels Alder technology by functionalization of amide-based monomers.International journal of medical sciences · 2011Article
- Extension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistry.International journal of medical sciences · 2010Article
- Gain of a 500-fold sensitivity on an intravital MR contrast agent based on an endohedral gadolinium-cluster-fullerene-conjugate: a new chance in cancer diagnostics.International journal of medical sciences · 2010Article
- The Diels-Alder-reaction with inverse-electron-demand, a very efficient versatile click-reaction concept for proper ligation of variable molecular partners.International journal of medical sciences · 2009Article
- High-resolution flow cytometry: a suitable tool for monitoring aneuploid prostate cancer cells after TMZ and TMZ-BioShuttle treatment.International journal of medical sciences · 2009Article
- New strategies to deliver anticancer drugs to brain tumors.Expert opinion on drug delivery · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a large number of effective cytotoxic drugs whose side effect profile, efficacy, and long-term use in man are well understood and documented over decades of use in clinical routine e.g. in the treatment of recurrent glioblastoma multiforme (GBM) and the hormone-refractory prostate cancer (HRPC). Both cancers are insensitive against most chemotherapeutic interventions; they have low response rates and poor prognoses. Some cytotoxic agents can be significantly improved by using modern technology of drug delivery or formulation. We succeeded to enhance the pharmacologic potency with simultaneous reduction of unwanted adverse reactions of the highly efficient chemotherapeutic temozolomide (TMZ) as an example. The TMZ connection to transporter molecules (TMZ-BioShuttle) resulted in a much higher pharmacological effect in glioma cell lines while using reduced doses. This permits the conclusion that a suitable chemistry could realize the ligation of pharmacologically active, but sensitive and highly unstable pharmaceutical ingredients without functional deprivation. The re-formulation of TMZ to TMZ-BioShuttle achieved a nearly 10-fold potential of the established pharmaceutic TMZ far beyond the treatment of brain tumors cells and results in an attractive reformulated drug with enhanced therapeutic index.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.