ReviewCurrent opinion in otolaryngology & head and neck surgery2008
Recent advances in hair cell regeneration research.
Review in Current opinion in otolaryngology & head and neck surgery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Precise genetic control of ATOH1 enhances maturation of regenerated hair cells in the mature mouse utricle.Nature communications · 2024Article
- Differential regulation of mammalian and avian ATOH1 by E2F1 and its implication for hair cell regeneration in the inner ear.Scientific reports · 2021Article
- Advances and challenges in adeno-associated viral inner-ear gene therapy for sensorineural hearing loss.Molecular therapy. Methods & clinical development · 2021Review
- Article
- RNA-Seq and microarray analysis of the Xenopus inner ear transcriptome discloses orthologous OMIM(®) genes for hereditary disorders of hearing and balance.BMC research notes · 2015Article
- Characterizing human vestibular sensory epithelia for experimental studies: new hair bundles on old tissue and implications for therapeutic interventions in ageing.Neurobiology of aging · 2015Article
- Lgr5+ cells regenerate hair cells via proliferation and direct transdifferentiation in damaged neonatal mouse utricle.Nature communications · 2015Article
- Changes in the adult vertebrate auditory sensory epithelium after trauma.Hearing research · 2013Review
- Intravital imaging of hair-cell development and regeneration in the zebrafish.Frontiers in neuroanatomy · 2013Article
- The cochlear implant: historical aspects and future prospects.Anatomical record (Hoboken, N.J. : 2007) · 2012Review
- The myc road to hearing restoration.Cells · 2012Article
- Identification of modulators of hair cell regeneration in the zebrafish lateral line.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Artificial induction of Sox21 regulates sensory cell formation in the embryonic chicken inner ear.PloS one · 2012Article
- Overactivation of Notch1 signaling induces ectopic hair cells in the mouse inner ear in an age-dependent manner.PloS one · 2012Article
- Article
- A review of gene delivery and stem cell based therapies for regenerating inner ear hair cells.Journal of functional biomaterials · 2011Article
- Molecular conversations and the development of the hair follicle and basal cell carcinoma.Cancer prevention research (Philadelphia, Pa.) · 2010Review
- The challenge of hair cell regeneration.Experimental biology and medicine (Maywood, N.J.) · 2010Review
- Regulation of cell fate and patterning in the developing mammalian cochlea.Current opinion in otolaryngology & head and neck surgery · 2009Article
- Feathers and fins: non-mammalian models for hair cell regeneration.Brain research · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewThis review discusses recent progress in research that seeks to understand the regeneration of hair cells and highlights findings that may hold importance for the eventual development of regenerative therapies for hearing and balance impairments. RECENT
findingsSignaling via the Notch receptor and the basic helix-loop-helix transcription factors has important roles in the development and regeneration of hair cells. The cytoskeletal properties and cell-matrix interactions of supporting cells in mice of different ages may hold part of the explanation for the age-related differences in their proliferative responses to damage and the differences between mammals and nonmammals in hair cell regeneration. Progress also has been made in deriving stem cells from inner ear tissues and other sources and in the evaluation of their potential uses as sources of new hair cells and as tools for biomedical research. SUMMARY: Much has been accomplished since the discovery of postembryonic hair cell production and hair cell regeneration in nonmammals decades ago. No therapies for hair cell regeneration are under clinical trials, but research is yielding potentially important discoveries that are likely to lead to the development of therapeutic methods for inducing hair cell regeneration in the mammalian inner ear.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.