ArticleBlood2008
Early chimerism threshold predicts sustained engraftment and NK-cell tolerance in prenatal allogeneic chimeras.
Article in Blood, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Thyroid autoimmunity and pre-term delivery: brief review and meta-analysis.Journal of endocrinological investigation · 2011Pooled it
- Immune modulation permits tolerance and engraftment in a murine model of late-gestation transplantation.Blood advances · 2024Article
- Maternal dendritic cells influence fetal allograft response following murine in-utero hematopoietic stem cell transplantation.Stem cell research & therapy · 2023Article
- Experimental and clinical progress of in utero hematopoietic cell transplantation therapy for congenital disorders.Frontiers in pharmacology · 2022Review
- Maternal microchimerism and cell-mediated immune-modulation enhance engraftment following semi-allogenic intrauterine transplantation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Trogocytosis between Non-Immune Cells for Cell Clearance, and among Immune-Related Cells for Modulating Immune Responses and Autoimmunity.International journal of molecular sciences · 2021Review
- Review
- Depletion of murine fetal hematopoietic stem cells with c-Kit receptor and CD47 blockade improves neonatal engraftment.Blood advances · 2018Article
- A comparison of intrauterine hemopoietic cell transplantation and lentiviral gene transfer for the correction of severe β-thalassemia in a HbbTh3/+ murine model.Experimental hematology · 2018Article
- Maternal and Fetal Immune Response to in Utero Stem Cell Transplantation.Current stem cell reports · 2018Article
- Systemic multilineage engraftment in mice after in utero transplantation with human hematopoietic stem cells.Blood advances · 2018Article
- Extrinsic allospecific signals of hematopoietic origin dictate iNKT cell lineage-fate decisions during development.Scientific reports · 2016Article
- Transplant Tolerance Induction in Newborn Infants: Mechanisms, Advantages, and Potential Strategies.Frontiers in immunology · 2016Review
- In utero stem cell transplantation and gene therapy: rationale, history, and recent advances toward clinical application.Molecular therapy. Methods & clinical development · 2016Review
- Prenatal Allogeneic Tolerance in Mice Remains Stable Despite Potent Viral Immune Activation.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Prenatal Allospecific NK Cell Tolerance Hinges on Instructive Allorecognition through the Activating Receptor during Development.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Review
- Partial rescue of mucopolysaccharidosis type VII mice with a lifelong engraftment of allogeneic stem cells in utero.Congenital anomalies · 2015Article
- NK cell tolerance as the final endorsement of prenatal tolerance after in utero hematopoietic cellular transplantation.Frontiers in pharmacology · 2015Review
- Influence of a dual-injection regimen, plerixafor and CXCR4 on in utero hematopoietic stem cell transplantation and engraftment with use of the sheep model.Cytotherapy · 2014Article
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Abstract
The failure of engraftment in human cases of in utero hematopoietic cell transplantation (IUHCT) in which no immunodeficiency exists suggests the presence of an unrecognized fetal immune barrier. A similar barrier in murine IUHCT appears to be dependent on the chimerism level and is poorly explained by a lack of T-cell tolerance induction. Therefore, we studied the effect of the chimerism level on engraftment and host natural killer (NK)-cell education in a murine model of IUHCT. The dose of transplanted cells was found to exhibit a strong correlation with both the engraftment rate and chimerism level. More specifically, a threshold level of initial chimerism (> 1.8%) was identified that predicted durable engraftment for allogeneic IUHCT, whereas low initial chimerism (< 1.8%) predicted a loss of engraftment. NK cells taken from chimeras above the "chimerism threshold" displayed durable calibration of alloresponsive Ly49A receptors and tolerance to donor antigens. Depletion of recipient NK cells stabilized engraftment in low-level chimeras (< 1.8%). These studies illustrate the importance of the early chimerism threshold in predicting long-term engraftment and host NK-cell tolerance after in utero transplantation.
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