ArticleProceedings of the National Academy of Sciences of the United States of America2008
Netrin-1 is a survival factor during commissural neuron navigation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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Who cites it
46 citing papers in PubMed, 70 citations in OpenAlex.
- Cancer-nervous system crosstalk: from biological mechanism to therapeutic opportunities.Molecular cancer · 2025Review
- DCC/netrin-1 regulates cell death in oligodendrocytes after brain injury.Cell death and differentiation · 2023Article
- UNC5C Receptor Proteolytic Cleavage by Active AEP Promotes Dopaminergic Neuronal Degeneration in Parkinson's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Frazzled/Dcc acts independently of Netrin to promote germline survival during Drosophila oogenesis.Development (Cambridge, England) · 2021Article
- Growth cone repulsion to Netrin-1 depends on lipid raft microdomains enriched in UNC5 receptors.Cellular and molecular life sciences : CMLS · 2021Article
- Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson's disease features.The EMBO journal · 2021Article
- PathogenicBrain communications · 2021Article
- UsingFrontiers in cell and developmental biology · 2021Review
- Article
- Polyomavirus Small T Antigen Induces Apoptosis in Mammalian Cells through the UNC5B Pathway in a PP2A-Dependent Manner.Journal of virology · 2020Article
- Blocking SHH/Patched Interaction Triggers Tumor Growth Inhibition through Patched-Induced Apoptosis.Cancer research · 2020Article
- Article
- The Role of Apoptotic Signaling in Axon Guidance.Journal of developmental biology · 2018Review
- Draxin regulates hippocampal neurogenesis in the postnatal dentate gyrus by inhibiting DCC-induced apoptosis.Scientific reports · 2018Article
- Distinct functions for netrin 1 in chicken and murine semicircular canal morphogenesis.Development (Cambridge, England) · 2017Article
- Neuroprotection Exerted by Netrin-1 and Kinesin Motor KIF1A in Secondary Brain Injury following Experimental Intracerebral Hemorrhage in Rats.Frontiers in cellular neuroscience · 2017Article
- Netrin-1 Prevents Rat Primary Cortical Neurons from Apoptosis via the DCC/ERK Pathway.Frontiers in cellular neuroscience · 2017Article
- Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3.Cell stem cell · 2016Article
- Neuronal Cell Bodies Remotely Regulate Axonal Growth Response to Localized Netrin-1 Treatment via Second Messenger and DCC Dynamics.Frontiers in cellular neuroscience · 2016Article
- Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance.Nature communications · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DCC (Deleted in Colorectal Cancer) is a putative tumor suppressor whose expression is lost in numerous cancers and whose tumor suppressor activity appears to be dependent on its ability to trigger apoptosis when disengaged by its ligand netrin-1. In this sense, netrin-1 is a survival factor that controls tumorigenesis. However, netrin-1 is also the prototypical axon guidance cue and has been shown to orient many neurons or axons, especially commissural axons, during spinal cord development. Here we show that netrin-1 is not only an attractive cue for developing commissural axons but also promotes their survival. In primary neuronal culture, in mice or in chick embryos, netrin-1 inhibits the proapoptotic activity of DCC in developing commissural neurons. Thus, adequate commissural neurons navigation requires both the attractive activity of netrin-1 and the anti-apoptotic function of this cue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.