ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2009
Oat5 and NaDC1 protein abundance in kidney and urine after renal ischemic reperfusion injury.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Paradoxical reduction of plasma lipids and atherosclerosis in mice with adenine-induced chronic kidney disease and hypercholesterolemia.Frontiers in cardiovascular medicine · 2023Article
- Renal tubular cell spliced X-box binding protein 1 (Xbp1s) has a unique role in sepsis-induced acute kidney injury and inflammation.Kidney international · 2019Article
- Renal expression and urinary excretion of NaPflugers Archiv : European journal of physiology · 2018Article
- Renal Expression and Urinary Excretion of Na-K-2Cl Cotransporter in Obstructive Nephropathy.BioMed research international · 2017Article
- The urinary excretion of an organic anion transporter as an early biomarker of methotrexate-induced kidney injury.Toxicology research · 2016Article
- Expression of renal Oat5 and NaDC1 transporters in rats with acute biliary obstruction.World journal of gastroenterology · 2015Article
- Sodium-coupled dicarboxylate and citrate transporters from the SLC13 family.Pflugers Archiv : European journal of physiology · 2014Review
- Hypoxia alters ocular drug transporter expression and activity in rat and calf models: implications for drug delivery.Molecular pharmaceutics · 2013Article
- Organic anion transporter 5 renal expression and urinary excretion in rats with vascular calcification.BioMed research international · 2013Article
- Renal organic anion transporters (SLC22 family): expression, regulation, roles in toxicity, and impact on injury and disease.The AAPS journal · 2013Review
- Gender related differences in kidney injury induced by mercury.International journal of molecular sciences · 2012Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate the abundance of the organic anion transporter 5 (Oat5) and the sodium-dicarboxylate cotransporter 1 (NaDC1) in kidney and urine after renal ischemic reperfusion injury. Renal injury was induced in male Wistar rats by occlusion of both renal pedicles for 0 (Group Sham), 5 (Group I5R60), or 60 (Group I60R60) min. The studies were performed after 60 min of reperfusion. The expression of Oat5 and NaDC1 was evaluated by IHC and Western blotting. Oat5 and NaDC1 abundance and alkaline phosphatase activity (AP) were assayed in urine. A decreased expression in renal homogenates and apical membranes and an increase in urinary excretion of Oat5 and NaDC1 were observed in I60R60 rats, as well as alterations of other widely used parameters for renal dysfunction and injury (plasma creatinine, urinary AP activity, kidney weight, histological lesions). In contrast, in the I5R60 group, only an increase in urinary excretion of Oat5 and mild histopathological damage was detected. This is the first study on Oat5 and NaDC1 detection in urine. These results suggest that urinary excretion of Oat5 might be an early indicator of renal dysfunction, which is useful for detection of even minor alterations in renal structural and functional integrity.
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