ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2009
Immunohistochemical localization of six galectin subtypes in the mouse digestive tract.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 81 citations in OpenAlex.
- Altered distribution of tissue galectins correlates with mucosal dysregulation in SIV infection.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Age-Related Transcriptomic Changes in the Vermiform Appendix.International journal of molecular sciences · 2025Article
- A Narrative Review on the Multifaceted Roles of Galectins in Host-Pathogen Interactions DuringInternational journal of molecular sciences · 2025Review
- Review
- Galectin-7 Expression in the Placentas of Women with Gestational Diabetes Mellitus.International journal of molecular sciences · 2024Article
- Identification and Characterization of Multiple Paneth Cell Types in the Mouse Small Intestine.Cells · 2024Article
- Galectin-2 AgglutinatesInternational journal of molecular sciences · 2024Article
- Analysis of the Interaction Between Mucin and Green Fluorescent Protein (GFP)-Tagged Galectin-2 Using a 96-Well Plate.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Heterogeneous murine peribiliary glands orchestrate compartmentalized epithelial renewal.Developmental cell · 2023Article
- Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis.Science advances · 2023Article
- Galectin-2 in Health and Diseases.International journal of molecular sciences · 2022Review
- Highlights on the Role of Galectin-3 in Colorectal Cancer and the Preventive/Therapeutic Potential of Food-Derived Inhibitors.Cancers · 2022Review
- Gal-2 Increases H3K4meBiomolecules · 2022Article
- Transcytosis of Galectin-3 in Mouse Intestine.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Human Galectin-7 GeneFrontiers in molecular neuroscience · 2022Article
- Galectin-2 Has Bactericidal Effects againstInternational journal of molecular sciences · 2020Article
- Article
- Immunological Effects of Human Milk Oligosaccharides.Frontiers in pediatrics · 2018Review
- Galectins in Intestinal Inflammation: Galectin-1 Expression Delineates Response to Treatment in Celiac Disease Patients.Frontiers in immunology · 2018Article
- Parallel mRNA, proteomics and miRNA expression analysis in cell line models of the intestine.World journal of gastroenterology · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Galectin, an animal lectin that recognizes beta-galactoside of glycoconjugates, is abundant in the gut. This IHC study showed the subtype-specific localization of galectin in the mouse digestive tract. Mucosal epithelium showed region/cell-specific localization of each galectin subtype. Gastric mucous cells exhibited intense immunoreactions for galectin-2 and galectin-4/6 with a limited localization of galectin-3 at the surface of the gastric mucosa. Electron microscopically, galectin-3 immunoreactivity coated indigenous bacteria on the gastric surface mucous cells. Epithelial cells in the small intestine showed characteristic localizations of galectin-2 and galectin-4/6 in the cytoplasm of goblet cells and the baso-lateral membrane of enterocytes in association with maturation, respectively. Galectin-3 expressed only at the villus tips was concentrated at the myosin-rich terminal web of fully matured enterocytes. Epithelial cells of the large intestine contained intense immunoreactions for galectin-3 and galectin-4/6 but not for galectin-2. The stratified squamous epithelium of the forestomach was immunoreactive for galectin-3 and galectin-7, but the basal layer lacked galectin-3 immunoreactivity. Outside the epithelium, only galectin-1 was localized in the connective tissue, smooth muscles, and neuronal cell bodies. The subtype-specific localization of galectin suggests its important roles in host-pathogen interaction and epithelial homeostasis such as membrane polarization and trafficking in the gut.
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