ArticleMarine biotechnology (New York, N.Y.)
Specific expression of BMP2/4 ortholog in biomineralizing tissues of corals and action on mouse BMP receptor.
Article in Marine biotechnology (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 61 citations in OpenAlex.
- Spatially resolved gene expression analysis illuminates location-specific functions in the reef-building coral Pocillopora acuta.PloS one · 2026Article
- Brine Shrimp Feeding Contributes to Fast Growth and Enhanced Immune Capacity of Reattached Polyps of Scleractinian CoralAnimals : an open access journal from MDPI · 2025Article
- Genomic signatures suggesting adaptation to ocean acidification in a coral holobiont from volcanic COCommunications biology · 2023Article
- Bone Morphogenetic Protein 2/4 in Mollusk, Haliotis diversicolor: Its Expression and Osteoinductive Function In Vitro.Marine biotechnology (New York, N.Y.) · 2021Article
- Deep-Sea Coral Garden Invertebrates and Their Associated Fungi Are Genetic Resources for Chronic Disease Drug Discovery.Marine drugs · 2021Article
- A role for primary cilia in coral calcification?Cell and tissue research · 2021Article
- PfSMAD1/5 Can Interact with PfSMAD4 to Inhibit PfMSX to Regulate Shell Biomineralization in Pinctada fucata martensii.Marine biotechnology (New York, N.Y.) · 2020Article
- Article
- Bioactive Compounds from Marine Organisms: Potential for Bone Growth and Healing.Marine drugs · 2018Review
- Coral cell separation and isolation by fluorescence-activated cell sorting (FACS).BMC cell biology · 2017Article
- Identifying genes and regulatory pathways associated with the scleractinian coral calcification process.PeerJ · 2017Article
- Molecular assessment of the effect of light and heterotrophy in the scleractinian coral Stylophora pistillata.Proceedings. Biological sciences · 2016Article
- Developmental Progression in the Coral Acropora digitifera Is Controlled by Differential Expression of Distinct Regulatory Gene Networks.Genome biology and evolution · 2016Article
- The genetics of colony form and function in Caribbean Acropora corals.BMC genomics · 2014Article
- Molecular characterization of the BMP7 gene and its potential role in shell formation in Pinctada martensii.International journal of molecular sciences · 2014Article
- Immunolocalization of skeletal matrix proteins in tissue and mineral of the coral Stylophora pistillata.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Evolving marine biomimetics for regenerative dentistry.Marine drugs · 2014Review
- Article
- The skeletal proteome of the coral Acropora millepora: the evolution of calcification by co-option and domain shuffling.Molecular biology and evolution · 2013Article
- A therapeutic potential for marine skeletal proteins in bone regeneration.Marine drugs · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor beta superfamily, and have been identified by their ability to induce bone formation in vertebrates. The biomineral-forming process, called biomineralization, is a widespread process, present in all kingdoms of living organisms and among which stony corals are one of the major groups of calcifying animals. Here, we report the presence of a BMP2/4 ortholog in eight species of adult corals. The synthesis of such a protein by the calcifying epithelium of corals suggests that coral BMP2/4 plays a role in skeletogenesis, making BMP the first common protein involved in biomineralization among Eumetazoans. In addition we show that recombinant coral BMP2/4 is able to inhibit human BMP2-induced osteoblastic differentiation in mesenchymal C2C12 cells. We suggest that this inhibition results from a competition between coral BMP2/4 and human BMP2, indicating conservation of binding affinity of BMP and its receptor during evolution from corals to vertebrates. Further studies are needed to understand interactions between coral BMP2/4 and its receptors, and, thus, the action of BMP2/4 in adult corals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.