ArticleEuropean journal of pediatrics2009
Clinical implications and prognostic value of EMMPRIN/CD147 and MMP2 expression in pediatric gliomas.
Article in European journal of pediatrics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- CD147 and glioma: a meta-analysis.Journal of neuro-oncology · 2017Pooled it
- Is CD147 a New Biomarker Reflecting Histological Malignancy of Gliomas?Molecular neurobiology · 2017Pooled it
- CD147/EMMPRIN overexpression and prognosis in cancer: A systematic review and meta-analysis.Scientific reports · 2016Pooled it
- Systematic review of protein biomarkers of invasive behavior in glioblastoma.Molecular neurobiology · 2014Pooled it
- A micelle-based stage-by-stage impelled system for efficient doxorubicin delivery.Bioactive materials · 2023Article
- Selected Matrix Metalloproteinases (MMP-2, MMP-7) and Their Inhibitor (TIMP-2) in Adult and Pediatric Cancer.Diagnostics (Basel, Switzerland) · 2020Review
- The clinicopathological significance and prognostic value of EMMPRIN overexpression in cancers: evidence from 39 cohort studies.Oncotarget · 2017Article
- Expression and prognostic impact of matrix metalloproteinase-2 (MMP-2) in astrocytomas.PloS one · 2017Article
- The effects of CD147 on the cell proliferation, apoptosis, invasion, and angiogenesis in glioma.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Article
- A novel small-molecule compound targeting CD147 inhibits the motility and invasion of hepatocellular carcinoma cells.Oncotarget · 2016Article
- Activation of NMDA receptor of glutamate influences MMP-2 activity and proliferation of glioma cells.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Article
- SELDI-TOF analysis of glioblastoma cyst fluid is an approach for assessing cellular protein expression.Neurological research · 2013Article
- EMMPRIN expression positively correlates with WHO grades of astrocytomas and meningiomas.Journal of neuro-oncology · 2013Article
- EMMPRIN/CD147 expression is associated with disease-free survival of patients with colorectal cancer.Medical oncology (Northwood, London, England) · 2013Article
- EMMPRIN is an independent negative prognostic factor for patients with astrocytic glioma.PloS one · 2013Article
- Increased CD147 and MMP-9 expression in the normal rat brain after gamma irradiation.Journal of radiation research · 2013Article
- New insights into germ cell migration and survival/apoptosis in spermatogenesis: Lessons from CD147.Spermatogenesis · 2012Article
- Treatment of high-grade glioma in children and adolescents.Neuro-oncology · 2011Review
- Molecular alterations in glioblastoma: potential targets for immunotherapy.Progress in molecular biology and translational science · 2011Review
- Evaluation of EMMPRIN and MMP-2 in the prognosis of primary cutaneous malignant melanoma.Medical oncology (Northwood, London, England) · 2010Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracellular matrix metalloproteinase inducer (EMMPRIN), a member of the immunoglobulin superfamily, is present on the surface of tumor cells where it stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPs). We have analyzed the clinicopathological characteristics of EMMPRIN and MMP2 expression in normal brain tissue and pediatric gliomas and evaluated their prognostic value in diagnosing the latter. Immunochemistry analysis revealed EMMPRIN and MMP2 expression in cryo-sections of pediatric gliomas (45 samples) and normal brain tissue (20 samples). Both EMMPRIN and MMP2 were expressed in normal brain and glioma tissues with different levels of malignancy. The intensively positive expression rates of EMMPRIN (22/27) and MMP2 (21/27) in anaplastic astrocytoma and glioblastoma tissues were significantly higher than those in normal brain and low-grade astrocytoma tissues (2/28 and (1/2)8, respectively). Spearman analysis indicated that the expression level of EMMPRIN was significantly positively correlated with that of MMP2 (r = 0.86, p < 0.01). The positive expression of EMMPRIN and MMP2 was associated with higher grade gliomas. Patients with EMMPRIN+/MMP2+ expression had the lowest survival rate (p < 0.01). Based on these results, we conclude that EMMPRIN and MMP2 are expressed differently in normal brain and pediatric gliomas. The detection of their co-expression may facilitate the prediction of pediatric gliomas prognosis.
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