ReviewPflugers Archiv : European journal of physiology2009
Function and regulation of claudins in the thick ascending limb of Henle.
Review in Pflugers Archiv : European journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 56 citations in OpenAlex.
- Actin cytoskeleton and associated myosin motors within the renal epithelium.American journal of physiology. Renal physiology · 2024Review
- Gene-nutrient interactions that impact magnesium homeostasis increase risk for neural tube defects in mice exposed to dolutegravir.Frontiers in cell and developmental biology · 2023Article
- Renal cell markers: lighthouses for managing renal diseases.American journal of physiology. Renal physiology · 2021Article
- Review
- Claudins in Renal Physiology and Pathology.Genes · 2020Review
- A Novel Hypokalemic-Alkalotic Salt-Losing Tubulopathy in Patients withJournal of the American Society of Nephrology : JASN · 2017Article
- AVP dynamically increases paracellular NaPflugers Archiv : European journal of physiology · 2017Review
- Identification of the first large deletion in the CLDN16 gene in a patient with FHHNC and late-onset of chronic kidney disease: case report.BMC nephrology · 2015Article
- Regulation of tight junction gene expression in the kidney of calbindin-D9k and/or -D28k knockout mice after consumption of a calcium- or a calcium/vitamin D-deficient diet.BMC biochemistry · 2014Article
- Changes of Tight Junction Protein Claudins in Small Intestine and Kidney Tissues of Mice Fed a DDC Diet.Journal of toxicologic pathology · 2013Article
- Claudins and the modulation of tight junction permeability.Physiological reviews · 2013Review
- Claudin-19 mutations and clinical phenotype in Spanish patients with familial hypomagnesemia with hypercalciuria and nephrocalcinosis.PloS one · 2013Article
- Complexity and developmental changes in the expression pattern of claudins at the blood-CSF barrier.Histochemistry and cell biology · 2012Article
- Claudins: control of barrier function and regulation in response to oxidant stress.Antioxidants & redox signaling · 2011Review
- Claudins in lung diseases.Respiratory research · 2011Review
- Renal, ocular, and neuromuscular involvements in patients with CLDN19 mutations.Clinical journal of the American Society of Nephrology : CJASN · 2011Article
- Differential expression of claudin tight junction proteins in the human cortical nephron.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2010Article
- A molecularly guided tour along the nephron.Pflugers Archiv : European journal of physiology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The thick ascending limb (TAL) of Henle mediates transcellular reabsorption of NaCl while generating a lumen-positive voltage that drives passive paracellular reabsorption of divalent cations. Disturbance of paracellular reabsorption leads to Ca(2+) and Mg(2+) wasting in patients with the rare inherited disorder of familial hypercalciuric hypomagnesemia with nephrocalcinosis (FHHNC). Recent work has shown that the claudin family of tight junction proteins form paracellular pores and determine the ion selectivity of paracellular permeability. Importantly, FHHNC has been found to be caused by mutations in two of these genes, claudin-16 and claudin-19, and mice with knockdown of claudin-16 reproduce many of the features of FHHNC. Here, we review the physiology of TAL ion transport, present the current view of the role and mechanism of claudins in determining paracellular permeability, and discuss the possible pathogenic mechanisms responsible for FHHNC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.