ArticlePsychopharmacology2008
Reduction in the latency of action of antidepressants by 17 beta-estradiol in the forced swimming test.
Article in Psychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 44 citations in OpenAlex.
- Combination of low doses of mirtazapine plus venlafaxine produces antidepressant-like effects in rats, without affecting male or female sexual behavior.Psychopharmacology · 2025Article
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- Chemical Constituents and Antidepressant-Like Effects in Ovariectomized Mice of the Ethanol Extract ofMolecules (Basel, Switzerland) · 2018Article
- Behavioral and biochemical sensitivity to low doses of ketamine: Influence of estrous cycle in C57BL/6 mice.Neuropharmacology · 2018Article
- The Post-Ovariectomy Interval Affects the Antidepressant-Like Action of Citalopram Combined with Ethynyl-Estradiol in the Forced Swim Test in Middle Aged Rats.Pharmaceuticals (Basel, Switzerland) · 2016Article
- The antidepressant-like effects of topiramate alone or combined with 17β-estradiol in ovariectomized Wistar rats submitted to the forced swimming test.Psychopharmacology · 2014Article
- Influence of acute or chronic administration of ovarian hormones on the effects of desipramine in the forced swim test in female rats.Psychopharmacology · 2014Article
- Glycine site N-methyl-D-aspartate receptor antagonist 7-CTKA produces rapid antidepressant-like effects in male rats.Journal of psychiatry & neuroscience : JPN · 2013Article
- Factors influencing behavior in the forced swim test.Physiology & behavior · 2013Review
- 17 β -Estradiol attenuates poststroke depression and increases neurogenesis in female ovariectomized rats.BioMed research international · 2013Article
- Forced swim test behavior in postpartum rats.Pharmacology, biochemistry, and behavior · 2010Article
- Chronic treatment with the selective NOP receptor antagonist [Nphe 1, Arg 14, Lys 15]N/OFQ-NH 2 (UFP-101) reverses the behavioural and biochemical effects of unpredictable chronic mild stress in rats.Psychopharmacology · 2009Article
- Estradiol impairs response inhibition in young and middle-aged, but not old rats.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleAntidepressants (ADs) are slow to produce their therapeutic effect. This long latency promotes the development of new strategies to short their onset of action. Previous reports indicated that 17beta-estradiol (E(2)) promotes the antidepressant-like activity of fluoxetine (FLX) and desipramine (DMI) in the forced swimming test (FST).
objectiveThe aim of the present work was to analyze if E(2) reduces the antidepressant-like onset of action of venlafaxine (VLX), FLX, and DMI. MATERIALS AND
methodsIndependent groups of ovariectomized female Wistar rats were tested in the FST and in the open field after chronic (1 to 14 days) treatment with VLX (20 mg/kg/day), FLX (1.25 mg/kg/day), or DMI (1.25 mg/kg/day) alone or in combination with a single injection of E(2) (2.5 microg/rat sc, 8 h before FST).
resultsVLX, FLX, or DMI by themselves at these doses did not induce changes in the FST at short intervals after their injection (from 1 to 7 days). The addition of E(2) promoted the antidepressant-like effect of VLX and DMI as early as day 1. Such action was also evident after 3, for FLX, and 14 days for both FLX and DMI, but not for VLX. The behavioral actions of these ADs combined with E(2) were not accompanied by increases in general activity in the open-field test.
conclusionE(2) clearly reduced the latency to the onset of action for these ADs in the FST. These results represent an interesting therapeutic strategy for the treatment of depression in perimenopausal women.
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Registered trials
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