ArticlePsychopharmacology2009
Medication-related pharmacological manipulations of nicotine self-administration in the rat maintained on fixed- and progressive-ratio schedules of reinforcement.
Article in Psychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Neurobiological and Neurophysiological Mechanisms Underlying Nicotine Seeking and Smoking Relapse.Molecular neuropsychiatry · 2019Review
- Effects of paclitaxel on mechanical sensitivity and morphine reward in male and female C57Bl6 mice.Experimental and clinical psychopharmacology · 2016Article
- Amitifadine, a triple monoamine re-uptake inhibitor, reduces nicotine self-administration in female rats.European journal of pharmacology · 2015Article
- Optimizing treatments for nicotine dependence by increasing cognitive performance during withdrawal.Expert opinion on drug discovery · 2014Review
- Prior exposure to THC increases the addictive effects of nicotine in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- The β2 nicotinic acetylcholine receptor subunit differentially influences ethanol behavioral effects in the mouse.Alcohol (Fayetteville, N.Y.) · 2013Article
- Translating the smoking cessation properties of the antidepressant nortriptyline using reinforcing, discriminative and aversive stimulus effects of nicotine in rats.Psychopharmacology · 2012Article
- Noradrenergic alpha1 receptors as a novel target for the treatment of nicotine addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
- Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA.Psychopharmacology · 2010Article
- Tobacco smoke exposure induces nicotine dependence in rats.Psychopharmacology · 2010Article
- Bupropion and nicotine enhance responding for nondrug reinforcers via dissociable pharmacological mechanisms in rats.Psychopharmacology · 2009Article
- Neuropharmacology of the interoceptive stimulus properties of nicotine.Current drug abuse reviews · 2009Review
Corrections and comments
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Authors and funding
3 authors.
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Abstract
rationaleThe use of animal models to study existing medications for smoking cessation can elucidate the mechanism(s) of action of cessation agents and further validate the models for medication development.
objectiveThe objective of the study was to evaluate the response of nicotine self-administration (NSA) to pharmacological agents related to the smoking cessation medication bupropion and to nicotine dosing mimicking nicotine replacement on fixed-ratio (FR) and progressive-ratio (PR) schedules of reinforcement. MATERIALS AND
methodsNSA was maintained at a nicotine dose of 30 microg/kg/infusion i.v. in rats trained on FR5 and PR40% schedules. Pharmacological manipulations related to bupropion were examined by treating animals with a dopamine reuptake inhibitor [GBR 12909 (GBR)], a norepinephrine reuptake inhibitor [nisoxetine (NIS)], and a nicotinic antagonist [dihydro-beta-erythroidine (DHbetaE)]. The effect of nicotine replacement was examined on the PR schedule by chronic dosing with osmotic minipumps.
resultsSignificant treatment effects occurred with NIS and combinations of NIS-DHbetaE and with GBR on response rates. Chronic nicotine dosing reduced self-administration. The two schedules yielded different results with some treatments.
conclusionsNoradrenergic-nicotinic cholinergic interactions and enhanced responding consequent to dopamine reuptake inhibition may be part of the complex behavioral pharmacology of bupropion-like compounds. Observation of differential results with the two schedules has implication for the use of self-administration techniques to elaborate the mechanisms of dependence as well as drug discovery.
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Registered trials
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