ArticleThe review of diabetic studies : RDS2008
Genetic Basis of Type 1 Diabetes: Similarities and Differences between East and West.
Article in The review of diabetic studies : RDS, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Genetic basis of Asian diabetes.Journal of diabetes investigation · 2026Review
- Fulminant type 1 diabetes with high-titer anti-glutamic acid decarboxylase antibodies: Likely rapid progression from stage 2 to 3.Journal of diabetes investigation · 2026Article
- Saliva as a potential and non-invasive approach to identify upregulated genes associated with comorbidities of T1DM: a brief report.European journal of medical research · 2025Article
- Anti-GAD antibody-negative, anti-IA2 antibody-positive slowly progressive insulin-dependent diabetes mellitus and Graves' disease preceded by childhood-onset minimal change nephrotic syndrome: a case report.Diabetology international · 2025Article
- Genetics of type-1 diabetes.Diabetology international · 2024Review
- Does HLA explain the high incidence of childhood-onset type 1 diabetes in the Canary Islands? The role of Asp57 DQB1 molecules.BMC pediatrics · 2024Article
- HLA-DRB1 and -DQB1 Alleles, Haplotypes and Genotypes in Emirati Patients with Type 1 Diabetes Underscores the Benefits of Evaluating Understudied Populations.Frontiers in genetics · 2022Article
- β-Cell failure in diabetes: Common susceptibility and mechanisms shared between type 1 and type 2 diabetes.Journal of diabetes investigation · 2021Review
- Prader-Willi Syndrome with Slowly Progressive Insulin-dependent Diabetes Mellitus.Internal medicine (Tokyo, Japan) · 2021Article
- Different interaction of onset age and duration of type 1 diabetes on the dynamics of autoantibodies to insulinoma-associated antigen-2 and zinc transporter 8.Journal of diabetes investigation · 2021Article
- Genetics of fulminant type 1 diabetes.Diabetology international · 2020Review
- Clinical and genetic characteristics of people with type 1 diabetes who have discrepancies in titers of anti-glutamic acid decarboxylase antibody measured by radioimmunoassay and enzyme-linked immunosorbent assay.Journal of diabetes investigation · 2020Article
- Genetic aspects of type 1 diabetes.Annals of pediatric endocrinology & metabolism · 2019Article
- Human Leukocyte Antigen (HLA) and Islet Autoantibodies Are Tools to Characterize Type 1 Diabetes in Arab Countries: Emphasis on Kuwait.Disease markers · 2019Review
- Glutamic Acid Decarboxylase Autoantibody-negative Slowly Progressive Type 1 Diabetes Mellitus: A Case Report and Literature Review.Internal medicine (Tokyo, Japan) · 2018Review
- Article
- Case of newly onset type 1 diabetes after highly active antiretroviral therapy against HIV infection.Journal of diabetes investigation · 2015Article
- Risk factors and primary prevention trials for type 1 diabetes.International journal of biological sciences · 2013Review
- Mitochondrial aldehyde dehydrogenase (ALDH2) protects against streptozotocin-induced diabetic cardiomyopathy: role of GSK3β and mitochondrial function.BMC medicine · 2012Article
- Genetics and pathogenesis of type 1 diabetes: prospects for prevention and intervention.Journal of diabetes investigation · 2011Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 1 diabetes is a multifactorial disease caused by a complex interaction of genetic and environmental factors. The genetic factors involved consist of multiple susceptibility genes, at least five of which, HLA, INS, CTLA4, PTPN22 and IL2RA/CD25, have been shown to be associated with type 1 diabetes in Caucasian (Western) populations, as has recently been confirmed by genome-wide association studies. It has been proposed, however, that the contribution of these genes to type 1 diabetes susceptibility may be different in Asian (Eastern) populations. HLA and INS genes are consistently associated with type 1 diabetes in both Caucasian and Asian populations, but apparent differences in disease-associated alleles and haplotypes are observed between Japanese and Caucasian subjects. The association of CTLA4 with type 1 diabetes is concentrated in a subset of patients with autoimmune thyroid disease (AITD) in both Japanese and Caucasian populations, while the association of PTPN22 with type 1 diabetes in Japanese and most Asian populations is not as clear as in Caucasians. IL2RA/CD25 genes seem to be similarly distributed in type 1 diabetes patients in the two populations, whereas genetic heterogeneity may exist regarding SUMO4, with an association of the M55V variant with type 1 diabetes observed in Asians, but not in Caucasians. Genome-wide association studies (GWA) are largely outstanding for Asian populations but they are now underway in Japan. This review reports on the discovered similarities and differences in susceptibility genes for type 1 diabetes between East and West and discusses the most recent observations made by the involved investigators.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.