ArticleEnvironmental health perspectives2008
Variants in iron metabolism genes predict higher blood lead levels in young children.
Article in Environmental health perspectives, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Exposure to Mixtures of Metals and Neurodevelopmental Outcomes: A Multidisciplinary Review Using an Adverse Outcome Pathway Framework.Risk analysis : an official publication of the Society for Risk Analysis · 2015Pooled it
- Bloodlettings in Hemochromatosis Result in Increased Blood Lead (Pb) Concentrations.Biological trace element research · 2023Article
- Improving Equitability and Inclusion for Testing and Detection of Lead Poisoning in US Children.The Milbank quarterly · 2023Article
- Association between Polymorphisms of Hemochromatosis (HFE), Blood Lead (Pb) Levels, and DNA Oxidative Damage in Battery Workers.International journal of environmental research and public health · 2023Article
- Assessing the contributions of metals in environmental media to exposure biomarkers in a region of ferroalloy industry.Journal of exposure science & environmental epidemiology · 2019Article
- HFE Gene Mutations and Iron Status in 100 Healthy Polish Children.Journal of pediatric hematology/oncology · 2017Article
- The impact of H63D HFE gene carriage on hemoglobin and iron status in children.Annals of hematology · 2016Article
- Variation in an Iron Metabolism Gene Moderates the Association Between Blood Lead Levels and Attention-Deficit/Hyperactivity Disorder in Children.Psychological science · 2016Article
- Linkage Analysis of Urine Arsenic Species Patterns in the Strong Heart Family Study.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
- Latent variable models for gene-environment interactions in longitudinal studies with multiple correlated exposures.Statistics in medicine · 2015Article
- Quality control and statistical modeling for environmental epigenetics: a study on in utero lead exposure and DNA methylation at birth.Epigenetics · 2015Article
- Relationship among maternal blood lead, ALAD gene polymorphism and neonatal neurobehavioral development.International journal of clinical and experimental pathology · 2015Article
- Maternal iron metabolism gene variants modify umbilical cord blood lead levels by gene-environment interaction: a birth cohort study.Environmental health : a global access science source · 2014Article
- The effect of the hemochromatosis (HFE) genotype on lead load and iron metabolism among lead smelter workers.PloS one · 2014Article
- Effect modification by transferrin C2 polymorphism on lead exposure, hemoglobin levels, and IQ.Neurotoxicology · 2013Article
- Continuing issues with Lead: Recent Advances in Detection.European journal of inorganic chemistry · 2013Article
- What do we know of childhood exposures to metals (arsenic, cadmium, lead, and mercury) in emerging market countries?International journal of pediatrics · 2013Article
- A latent variable approach to study gene-environment interactions in the presence of multiple correlated exposures.Biometrics · 2012Article
- Exploring potential sources of differential vulnerability and susceptibility in risk from environmental hazards to expand the scope of risk assessment.American journal of public health · 2011Article
- Associations of iron metabolism genes with blood manganese levels: a population-based study with validation data from animal models.Environmental health : a global access science source · 2011Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundGiven the association between iron deficiency and lead absorption, we hypothesized that variants in iron metabolism genes would predict higher blood lead levels in young children.
objectiveWe examined the association between common missense variants in the hemochromatosis (HFE) and transferrin (TF) genes and blood lead levels in 422 Mexican children.
methodsArchived umbilical cord blood samples were genotyped for HFE (H63D and C282Y) and TF (P570S) variants. Blood lead was measured at 24, 30, 36, 42, and 48 months of age. A total of 341 subjects had at least one follow-up blood lead level available and data available on covariates of interest for inclusion in the longitudinal analyses. We used random-effects models to examine the associations between genotype (HFE, TF, and combined HFE + TF) and repeated measures of blood lead, adjusting for maternal blood lead at delivery and child's concurrent anemia status.
resultsOf 422 children genotyped, 17.7, 3.3, and 18.9% carried the HFE H63D, HFE C282Y, and TF P570S variants, respectively. One percent of children carried both the HFE C282Y and TF P570S variants, and 3% of children carried both the HFE H63D and TF P570S variants. On average, carriers of either the HFE (beta = 0.11, p = 0.04) or TF (beta = 0.10, p = 0.08) variant had blood lead levels that were 11% and 10% higher, respectively, than wild-type subjects. In models examining the dose effect, subjects carrying both variants (beta = 0.41, p = 0.006) had blood lead 50% higher than wild-type subjects and a significantly higher odds of having a blood lead level > 10 microg/dL (odds ratio = 18.3; 95% confidence interval, 1.9-177.1).
conclusionsIron metabolism gene variants modify lead metabolism such that HFE variants are associated with increased blood lead levels in young children. The joint presence of variant alleles in the HFE and TF genes showed the greatest effect, suggesting a gene-by-gene-by-environment interaction.
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