ReviewMolecules (Basel, Switzerland)2008
Application of metabolic engineering to the production of scopolamine.
Review in Molecules (Basel, Switzerland), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 87 citations in OpenAlex.
- Article
- The high production of tropane alkaloids in hairy roots of Hyoscyamus reticulatus L. elicited by ZnO NPs in a bioreactor condition.Scientific reports · 2025Article
- Identification ofFrontiers in microbiology · 2025Article
- Modulation of Tropane Alkaloids' Biosynthesis and Gene Expression by Methyl Jasmonate inLife (Basel, Switzerland) · 2024Article
- From Nature to Lab: A Review of Secondary Metabolite Biosynthetic Pathways, Environmental Influences, and In Vitro Approaches.Metabolites · 2023Review
- Effect of silver nanoparticles on tropane alkaloid production of transgenic hairy root cultures of Hyoscyamus muticus L. and their antimicrobial activity.Scientific reports · 2023Article
- Hairy root culture: a potent method for improved secondary metabolite production of Solanaceous plants.Frontiers in plant science · 2023Review
- Beauty of the beast: anticholinergic tropane alkaloids in therapeutics.Natural products and bioprospecting · 2022Review
- Regioselectivity of hyoscyamine 6β-hydroxylase-catalysed hydroxylation as revealed by high-resolution structural information and QM/MM calculations.Dalton transactions (Cambridge, England : 2003) · 2020Article
- Influence of nano-zinc oxide on tropane alkaloid production,Engineering in life sciences · 2019Article
- Targeted expression of Vitreoscilla hemoglobin improves the production of tropane alkaloids in Hyoscyamus niger hairy roots.Scientific reports · 2018Article
- Silencing of quinolinic acid phosphoribosyl transferase (QPT) gene for enhanced production of scopolamine in hairy root culture of Duboisia leichhardtii.Scientific reports · 2018Article
- Isolation, expression and biochemical characterization of recombinant hyoscyamine-6β-hydroxylase fromMedChemComm · 2018Article
- Biotic elicitation for scopolamine production by hairy root cultures ofMolecular biology research communications · 2017Article
- Exploiting members of the BAHD acyltransferase family to synthesize multiple hydroxycinnamate and benzoate conjugates in yeast.Microbial cell factories · 2016Article
- Transcriptome exploration for further understanding of the tropane alkaloids biosynthesis in Anisodus acutangulus.Molecular genetics and genomics : MGG · 2015Article
- Assessing the tobacco-rattle-virus-based vectors system as an efficient gene silencing technique in Datura stramonium (Solanaceae).Virus genes · 2014Article
- Production of tropane alkaloids in Hyoscyamus niger (black henbane) hairy roots grown in bubble-column and spray bioreactors.Biotechnology letters · 2014Article
- Article
- In vitro production of alkaloids: Factors, approaches, challenges and prospects.Pharmacognosy reviews · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scopolamine is an alkaloid widely used in medicine for its anticholinergic activity. The aim of this review is to show that metabolic engineering techniques constitute a suitable tool to improve the production of tropane alkaloids, focusing in particular on scopolamine. We present an overview of results obtained by various research groups, including our own, who have studied the overexpression of genes involved in the biosynthesis of scopolamine in different plant species that produce tropane alkaloids. Experiments carried out to improve production in hairy root cultures will also be described, as well as those attempting to biotransform hyoscyamine into scopolamine in roots and transgenic tobacco cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.