Evidence map›Paper›PMID 18794387›Full record

ArticleAntimicrobial agents and chemotherapy2008

Inhibition of voriconazole metabolism by chloramphenicol in an adolescent with central nervous system aspergillosis.

Verena Hafner, Nadine Albermann, Walter E Haefeli, Friedrich Ebinger

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Effects of CYP3A4 polymorphisms on the plasma concentration of voriconazole.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Verena HafnerDepartment of Internal Medicine VI, Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany.
Nadine Albermann
Walter E Haefeli
Friedrich Ebinger
Heidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For an adolescent with bacterial meningitis and subsequent cerebral aspergillosis, intravenous voriconazole dose requirements substantially decreased during coadministration with intravenous chloramphenicol and considerably rose after discontinuation of the antibiotic. In agreement with in vitro evidence, these data suggest that chloramphenicol is a rather significant inhibitor of hepatic CYP3A4 and/or CYP2C19.

Indexed as

AdolescentAnti-Bacterial AgentsAntifungal AgentsAryl Hydrocarbon HydroxylasesChloramphenicolCytochrome P-450 CYP2C19Cytochrome P-450 CYP3ACytochrome P-450 CYP3A InhibitorsDrug InteractionsEnzyme InhibitorsHumansLiverMaleNeuroaspergillosisPyrimidinesTriazolesAnti-Bacterial AgentsAntifungal AgentsAryl Hydrocarbon HydroxylasesChloramphenicolCYP2C19 protein, humanCYP3A4 protein, humanCytochrome P-450 CYP2C19Cytochrome P-450 CYP3ACytochrome P-450 CYP3A InhibitorsEnzyme InhibitorsPyrimidinesTriazolesVoriconazole

Identifiers

PMID18794387
PMCPMC2573136
OpenAlexW2161546718

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.