ArticleBiochemical and biophysical research communications2008
ATP-binding cassette transporters ABCA1, ABCA7, and ABCG1 in mouse spermatozoa.
Article in Biochemical and biophysical research communications, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 58 citations in OpenAlex.
- Potential effects on the signaling network mediated by overexpression of the vitronectin gene in Hu sheep ruminal epithelial cells using multi-omics analysis.Frontiers in genetics · 2026Article
- HDL mediates reverse cholesterol transport from ram spermatozoa and induces hyperactivated motility.Biology of reproduction · 2021Article
- A systems biology framework integrating GWAS and RNA-seq to shed light on the molecular basis of sperm quality in swine.Genetics, selection, evolution : GSE · 2020Article
- Extracellular Vesicles and the Oviduct Function.International journal of molecular sciences · 2020Review
- Dependence of sperm structural and functional integrity on testicular calcineurin isoform PPP3R2 expression.Journal of molecular cell biology · 2020Article
- Transcriptome profiling of porcine testis tissue reveals genes related to sperm hyperactive motility.BMC veterinary research · 2020Article
- The ABCA1 blocking agent probucol decreases capacitation in ejaculated dog spermatozoa.Acta veterinaria Scandinavica · 2020Article
- BODIPY-cholesterol can be reliably used to monitor cholesterol efflux from capacitating mammalian spermatozoa.Scientific reports · 2019Article
- Regulation of metabolism and transport of sphingosine-1-phosphate in mammalian cells.Molecular and cellular biochemistry · 2012Review
- Development of a cell-based, high-throughput screening assay for cholesterol efflux using a fluorescent mimic of cholesterol.Assay and drug development technologies · 2011Article
- Drug transporters, the blood-testis barrier, and spermatogenesis.The Journal of endocrinology · 2011Review
- Epididymis cholesterol homeostasis and sperm fertilizing ability.Asian journal of andrology · 2011Review
- Effects of human follicular fluid and high-density lipoproteins on early spermatozoa hyperactivation and cholesterol efflux.Journal of lipid research · 2010Article
- Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice.The Journal of clinical investigation · 2010Article
- Drug transporter, P-glycoprotein (MDR1), is an integrated component of the mammalian blood-testis barrier.The international journal of biochemistry & cell biology · 2009Article
- LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell-specific manner.Journal of lipid research · 2009Article
- New insights into the regulation of cholesterol efflux from the sperm membrane.Asian journal of andrologyReview
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Mammalian spermatozoa lose plasma membrane cholesterol during their maturation in the epididymis and during their capacitation in the female reproductive tract. While acceptors such as high-density lipoproteins (HDL) and apolipoproteins A-I (apoA-I) and J have been found in male and female reproductive tracts, transporters that mediate cholesterol efflux from plasma membranes of spermatozoa to such acceptors have not yet been defined. Candidate transporters are members of the ATP-binding cassette (ABC) transporter superfamily including ABCA1, ABCA7, ABCG1 and ABCG4, which have all been implicated in the transport of sterols and phospholipids to apolipoproteins and HDL. Here we show that mouse spermatozoa in the seminiferous tubules and epididymis express ABCA1, ABCA7 and ABCG1, but not ABCG4. Moreover, we show that ABCA1, ABCA7, and ABCG1 antibodies decrease cholesterol efflux from spermatozoa to lipid acceptors apoA-I and albumin and inhibit in vitro fertilization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.