ArticleChild and adolescent psychiatry and mental health2008
Off-label psychopharmacologic prescribing for children: history supports close clinical monitoring.
Article in Child and adolescent psychiatry and mental health, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Predictors of polypharmacy and off-label prescribing of psychotropic medications: a national survey of child and adolescent psychiatrists.Journal of psychiatric practice · 2014Pooled it
- Psychotropic Medication Use by Children with Autism Served in Publicly Funded Mental Health Settings.Journal of developmental and behavioral pediatrics : JDBPTrial
- Off-label drug use in children and adolescents treated with antidepressants and antipsychotics: results from a prospective multicenter trial.Child and adolescent psychiatry and mental health · 2025Article
- Off-label use of psychotropic drugs in youth.BMC psychiatry · 2025Article
- Physiologically-Based Pharmacokinetic Modeling of Total and Unbound Valproic Acid to Evaluate Dosing in Children With and Without Hypoalbuminemia.Clinical pharmacokinetics · 2024Article
- Predictors of valproic acid steady-state serum levels in adult and pediatric psychiatric inpatients: a comparative analysis.Psychopharmacology · 2024Article
- Reforming Paediatric Drug Regulations in Canada: A Clinical and an Access Imperative.Healthcare policy = Politiques de sante · 2023Article
- A longitudinal study of cytochrome P450 2D6 (CYP2D6) activity during adolescence.Clinical and translational science · 2022Article
- Serious Adverse Drug Reactions in Children and Adolescents Treated On- and Off-Label with Antidepressants and Antipsychotics in Clinical Practice.Pharmacopsychiatry · 2022Article
- Neuroprotection in late life attention-deficit/hyperactivity disorder: A review of pharmacotherapy and phenotype across the lifespan.Frontiers in human neuroscience · 2022Review
- Trends in antipsychotic prescribing for approved and unapproved indications to Medicaid-enrolled youth in Philadelphia, Pennsylvania between 2014 and 2018.BMC psychiatry · 2021Article
- Exploration and Ethical Analysis of Open-label Pediatric Vaccine Trials in a Pandemic.Clinical therapeutics · 2021Article
- Risk of seizures associated with antipsychotic treatment in pediatrics with psychiatric disorders: a nested case-control study in Korea.European child & adolescent psychiatry · 2021Article
- Cardiovascular Risk of Concomitant Use of Atypical Antipsychotics and Stimulants Among Commercially Insured Youth in the United States.Frontiers in psychiatry · 2021Article
- Concomitant Use of Psychotropic Medication With Stimulants for the Treatment of ADHD in Children and Adolescents: A Retrospective Insurance Claims Study in the United States.Journal of attention disorders · 2020Article
- Improving paediatric medications: A prescription for Canadian children and youth.Paediatrics & child health · 2019Review
- Pharmacovigilance in perspective: drug withdrawals, data mining and policy implications.F1000Research · 2019Review
- Association between serotonin 2C receptor gene (HTR2C) polymorphisms and psychopathological symptoms in children and adolescents.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018Article
- Methylphenidate and atomoxetine prescribing trends in children in the Western Cape Province of South Africa, 2005-2013.Health SA = SA Gesondheid · 2018Article
- Hispanic Residential Isolation, ADHD Diagnosis and Stimulant Treatment among Medicaid-Insured Youth.Ethnicity & disease · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The review presents pediatric adverse drug events from a historical perspective and focuses on selected safety issues associated with off-label use of medications for the psychiatric treatment of youth. Clinical monitoring procedures for major psychotropic drug classes are reviewed. Prior studies suggest that systematic treatment monitoring is warranted so as to both minimize risk of unexpected adverse events and exposures to ineffective treatments. Clinical trials to establish the efficacy and safety of drugs currently being used off-label in the pediatric population are needed. In the meantime, clinicians should consider the existing evidence-base for these drugs and institute close clinical monitoring.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.