ArticleBMC biochemistry2008
YB-1 promotes microtubule assembly in vitro through interaction with tubulin and microtubules.
Article in BMC biochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Similar Normalizing Effect of HSP70 and YB-1 Stress Proteins on the Brain Transcription of a Mouse Model of Alzheimer's Disease.Molecular neurobiology · 2025Article
- YB-1 Phosphorylation at Serine 209 Inhibits Its Nuclear Translocation.International journal of molecular sciences · 2021Article
- β-Barrels and Amyloids: Structural Transitions, Biological Functions, and Pathogenesis.International journal of molecular sciences · 2021Review
- Extracellular histones, a new class of inhibitory molecules of CNS axonal regeneration.Brain communications · 2021Article
- Article
- Y-Box Binding Protein 1 Stabilizes Hepatitis C Virus NS5A via Phosphorylation-Mediated Interaction with NS5A To Regulate Viral Propagation.Journal of virology · 2015Article
- Article
- Influenza Virus Induces Cholesterol-Enriched Endocytic Recycling Compartments for Budozone Formation via Cell Cycle-Independent Centrosome Maturation.PLoS pathogens · 2015Article
- The Y-Box Binding Protein 1 Suppresses Alzheimer's Disease Progression in Two Animal Models.PloS one · 2015Article
- A host YB-1 ribonucleoprotein complex is hijacked by hepatitis C virus for the control of NS3-dependent particle production.Journal of virology · 2013Article
- Structural basis for the association of MAP6 protein with microtubules and its regulation by calmodulin.The Journal of biological chemistry · 2013Article
- YB-1 functions as a porter to lead influenza virus ribonucleoprotein complexes to microtubules.Journal of virology · 2012Article
- The p63 protein isoform ΔNp63α modulates Y-box binding protein 1 in its subcellular distribution and regulation of cell survival and motility genes.The Journal of biological chemistry · 2012Article
- Article
- Y-box-binding protein 1 interacts with hepatitis C virus NS3/4A and influences the equilibrium between viral RNA replication and infectious particle production.Journal of virology · 2011Article
- Rapid assembly and collective behavior of microtubule bundles in the presence of polyamines.Biophysical journal · 2011Article
- Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1.Oncogene · 2010Article
- YB-1 binds to GluR2 mRNA and CaM1 mRNA in the brain and regulates their translational levels in an activity-dependent manner.Cellular and molecular neurobiology · 2010Article
- YB-1 alters MT1-MMP trafficking and stimulates MCF-7 breast tumor invasion and metastasis.Biochemical and biophysical research communications · 2010Article
- Molecular composition of staufen2-containing ribonucleoproteins in embryonic rat brain.PloS one · 2010Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundYB-1 is a major regulator of gene expression in eukaryotic cells. In addition to its role in transcription, YB-1 plays a key role in translation and stabilization of mRNAs.
resultsWe show here that YB-1 interacts with tubulin and microtubules and stimulates microtubule assembly in vitro. High resolution imaging via electron and atomic force microscopy revealed that microtubules assembled in the presence of YB-1 exhibited a normal single wall ultrastructure and indicated that YB-1 most probably coats the outer microtubule wall. Furthermore, we found that YB-1 also promotes the assembly of MAPs-tubulin and subtilisin-treated tubulin. Finally, we demonstrated that tubulin interferes with RNA:YB-1 complexes.
conclusionThese results suggest that YB-1 may regulate microtubule assembly in vivo and that its interaction with tubulin may contribute to the control of mRNA translation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.