Evidence map›Paper›PMID 18792766›Full record

ArticleJournal of clinical immunology2008

Limited T-cell receptor diversity predisposes to Th2 immunopathology: involvement of Tregs and conventional CD4 T cells.

Joshua Milner, William E Paul

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Joshua MilnerLaboratory of Immunology, NIAID, NIH, 9000 Rockville Pike, NIH Building 10-11N311, Bethesda, MD 208922, USA.
William E Paul
National Institutes of Health · US

Funding

Lymphocyte DynamicsZ01AI000926 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI PAUL, WILLIAM E. · 2003 to 2008
$3.3M
Eosinophilic Inflammatory Disease in Mice with Limited TCR RepertoireZ01AI000968 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI PAUL, WILLIAM E. · 2006 to 2008
$725k
Intramural NIH HHS Z01 AI000926Intramural NIH HHS Z01 AI000968
6 · The paper itself

Abstract

introductionA variety of immunodeficiencies characterized by limitations in the T-cell repertoire are also associated with Th2-like immunopathology.

methodsWe established a model of this phenomenon by transferring limited numbers of mature CD4+ T-cells into lymphopenic mice.

resultThis transfer resulted in eosinophilic pneumonia with alternatively activated macrophages, eosinophilic gastritis, and other organ infiltration, associated with elevated IgE levels and Th2 cytokine production by the transferred cells. Transfer of large numbers of T-cells did not result in any pathology. The disease could be suppressed by CD25+ Foxp3+ regulatory T cells, but only when the T-cell receptor repertoire of the Tregs was diverse.

conclusionCollectively, the data suggest that limited T-cell receptor repertoires derived from normal CD4+ T cells can cause severe Th2 immunopathology, and that failure of control by Tregs due to limitation of their repertoire is partially responsible for this phenotype.

Indexed as

AnimalsCD3 ComplexCD4-Positive T-LymphocytesGastritisImmunologic Deficiency SyndromesLungMiceMice, Inbred C57BLMice, KnockoutPulmonary EosinophiliaReceptors, Antigen, T-CellTh2 CellsT-Lymphocytes, RegulatoryCD3 ComplexCd3e protein, mouseReceptors, Antigen, T-Cell

Identifiers

PMID18792766
PMCPMC2760845
OpenAlexW2025575890

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.