Evidence map›Paper›PMID 18792422›Full record

ReviewNMR in biomedicine2008

Layer-specific anatomical, physiological and functional MRI of the retina.

Timothy Q Duong, Machelle T Pardue, Peter M Thulé, Darin E Olson, Haiying Cheng, Govind Nair, Yingxia Li, Moon Kim, Xiaodong Zhang, Qiang Shen

Open access · greenAbstract readReview
In one paragraph

Review in NMR in biomedicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 57 citations in OpenAlex.

  1. UltrasensitiveAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Whole-globe biomechanics using high-field MRI.Experimental eye research · 2017
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Decreased retinal-choroidal blood flow in retinitis pigmentosa as measured by MRI.Documenta ophthalmologica. Advances in ophthalmology · 2013
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Blood flow MRI of the human retina/choroid during rest and isometric exercise.Investigative ophthalmology & visual science · 2012
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Timothy Q DuongDepartment of Neurology and Radiology, Division of Neuroscience, Yerkes Research Center, Yerkes Imaging Center, Emory University, Atlanta, Georgia 30329, USA. tduong@emory.edu
Machelle T Pardue
Peter M Thulé
Darin E Olson
Haiying Cheng
Govind Nair
Yingxia Li
Moon Kim
Xiaodong Zhang
Qiang Shen
Imaging Center · USEmory University · USVeterans Health Administration · US

Funding

YNPRC NHP CLINICAL MEDICINE RESIDENCY PROGRAM - SUPPLEMENTP51RR000165 · NCRR · EMORY UNIVERSITY · PI ALTMAN, JOHN DAVID · 1985 to 2011
$114.0M
P30-Core Grant for Vision Research Core CP30EY006360 · NEI · EMORY UNIVERSITY · PI BOATRIGHT, JEFFREY H · 1986 to 2025
$15.3M
Layer-Specific Functional &Perfusion Imaging of RetinaR01EY014211 · NEI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DUONG, TIMOTHY Q. · 2004 to 2011
$3.0M
NCRR NIH HHS P51 RR000165NEI NIH HHS P30 EY006360NEI NIH HHS R01 EY014211
6 · The paper itself

Abstract

Most retinal imaging has been performed using optical techniques. This paper reviews alternative retinal imaging methods based on MRI performed with spatial resolution sufficient to resolve multiple well-defined retinal layers. The development of these MRI technologies to study retinal anatomy, physiology (blood flow, blood volume, and oxygenation) and function, and their applications to the study of normal retinas, retinal degeneration and diabetic retinopathy in animal models are discussed. Although the spatiotemporal resolution of MRI is poorer than that of optical imaging techniques, it is unhampered by media opacity and can thus image all retinal and pararetinal structures, and has the potential to provide multiple unique clinically relevant data in a single setting and could thus complement existing retinal imaging techniques. In turn, the highly structured retina with well-defined layers is an excellent model for advancing emerging high-resolution anatomical, physiological and functional MRI technologies.

Indexed as

AnimalsCarbon DioxideDiabetic RetinopathyMagnetic Resonance ImagingOxygenPhotic StimulationRegional Blood FlowRetinaRetinal DiseasesCarbon DioxideOxygen

Identifiers

PMID18792422
PMCPMC2752861
OpenAlexW1995294943

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.