ArticleDevelopment genes and evolution2008
Unexpectedly large number of conserved noncoding regions within the ancestral chordate Hox cluster.
Article in Development genes and evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- The EJC component Magoh in non-vertebrate chordates.Development genes and evolution · 2020Article
- Roles of Retinoic Acid Signaling in Shaping the Neuronal Architecture of the Developing Amphioxus Nervous System.Molecular neurobiology · 2018Article
- Conserved Noncoding Elements in the Most Distant Genera of Cephalochordates: The Goldilocks Principle.Genome biology and evolution · 2016Article
- Evolution of Hox gene clusters in deuterostomes.BMC developmental biology · 2013Review
- Broken colinearity of the amphioxus Hox cluster.EvoDevo · 2012Article
- An ancient genomic regulatory block conserved across bilaterians and its dismantling in tetrapods by retrogene replacement.Genome research · 2012Article
- Comparative genomics of the Hedgehog loci in chordates and the origins of Shh regulatory novelties.Scientific reports · 2012Article
- Evolution of anterior Hox regulatory elements among chordates.BMC evolutionary biology · 2011Article
- Evolution of conserved non-coding sequences within the vertebrate Hox clusters through the two-round whole genome duplications revealed by phylogenetic footprinting analysis.Journal of molecular evolution · 2010Article
- Conservation of gene linkage in dispersed vertebrate NK homeobox clusters.Development genes and evolution · 2009Article
- The amphioxus genome sequence illuminates the evolutionary origin of vertebrates.Development genes and evolution · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The single amphioxus Hox cluster contains 15 genes and may well resemble the ancestral chordate Hox cluster. We have sequenced the Hox genomic complement of the European amphioxus Branchiostoma lanceolatum and compared it to the American species, Branchiostoma floridae, by phylogenetic footprinting to gain insights into the evolution of Hox gene regulation in chordates. We found that Hox intergenic regions are largely conserved between the two amphioxus species, especially in the case of genes located at the 3' of the cluster, a trend previously observed in vertebrates. We further compared the amphioxus Hox cluster with the human HoxA, HoxB, HoxC, and HoxD clusters, finding several conserved noncoding regions, both in intergenic and intronic regions. This suggests that the regulation of Hox genes is highly conserved across chordates, consistent with the similar Hox expression patterns in vertebrates and amphioxus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.