ReviewDer Pathologe2008
[Systemic treatment of advanced colorectal cancer].
Review in Der Pathologe, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The introduction of modern chemotherapeutic drugs and targeted therapies has substantially changed the treatment of advanced colorectal cancer (aCRC). Thus, median survival of stage IV patients was increased from 6 months under best supportive care to over 2 years if all drugs are administered. Also, new combination therapies may cause irresectable liver metastases to shrink to such an extent that they may be resected (downsizing). Patients who were formerly treated with palliative intent may now be cured. However, not all patients benefit from the new compounds. Very recently, new genetic characteristics were identified as potential molecular biomarkers that may predict response to anti-EGFR therapy, a specific targeted therapy; the marker detected is the mutational status of the oncogene k-ras. Only patients with wild-type k-ras-expressing tumors respond to anti-EGFR antibodies. The integration of biomarker analysis into the clinical routine represents an important step toward customized treatment of cancer patients.
Indexed as
Identifiers
18791719What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.